MDM2

Cat. No.

A10657

CAS No.

548472-68-0

Nutlin-3

MDM2 antagonist nutlin-3 is a potent inducer of apoptosis.

Cat. No.

A14118

CAS No.

1364488-67-4

YH239-EE

YH239-EE is a potent p53-MDM2 antagonist and an apoptosis inducer.

Cat. No.

A11502

CAS No.

675576-97-3

Nutlin 3b

Synonyms: (+)-Nutlin-3

Nutlin 3b is a p53/MDM2 antagonist or inhibitor with IC50 value of 13.6 uM, 150-fold less potent (+)-enantiomer of Nutlin-3 as in comparison with opposite (-)-enantiomer Nutlin-3a.

Cat. No.

A15440

CAS No.

1303607-60-4

MI-773

Synonyms: SAR405838

MI-773 is an orally available MDM2 antagonist with Ki of 0.88 nM.

Cat. No.

A30156

CAS No.

2713618-08-5

Seldegamadlin

Synonyms: KT-253

Seldegamadlin is a selective p53 stabilizer and an MDM2 PROTAC degrader with a DC50 of 0.4 nM. It effectively inhibits the proliferation of RS4;11 cancer cells, demonstrating an IC50 of 0.3 nM, and induces cell cycle arrest at the G2/M phase while promoting apoptosis. By upregulating p53 activity, Seldegamadlin overcomes the p53-MDM2 feedback loop, making it a valuable tool for research in hematologic and solid tumors, including acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL).

Cat. No.

A33129

CAS No.

890090-75-2

(Rac)-Nutlin-3

Synonyms: (Rac)-Rebemadlin

(Rac)-Nutlin-3 is a potent antagonist of the murine double minute protein 2 (MDM2), with an IC50 of 90 nM. This compound effectively disrupts the interaction between MDM2 and p53, leading to stabilization of the p53 protein. Additionally, (Rac)-Nutlin-3 promotes cell autophagy and apoptosis, making it a valuable tool for investigating the roles of MDM2 in TP53 wild-type ovarian carcinomas and other related cancer research applications.

Cat. No.

A53898

CAS No.

908027-55-4

MI-219

MI-219 is an MDM2 antagonist with a Ki of 13.3 μM, specifically designed to disrupt the interaction between MDM2 and p53. This compound effectively inhibits the proliferation of FSCCL cells, demonstrated by an IC50 of 2.5 μM. MI-219 is suitable for research applications focused on cancer biology, particularly in studies exploring pathways related to tumor suppression and the p53 signaling axis.

Cat. No.

A53904

CAS No.

548472-58-8

Nutlin 1

Nutlin 1 is a potent MDM2 antagonist that reactivates the p53 pathway, playing a critical role in cell cycle regulation and apoptosis. With an IC50 of 0.26 μM, it effectively disrupts the MDM2-p53 interaction, promoting p53-mediated transcriptional activity. This compound is widely used in cancer research to explore the therapeutic potential of p53 reactivation in tumor cells.