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MDM2

MDM2 inhibitors disrupt the binding of mouse double minute 2 homolog (MDM2) to the tumor suppressor p53. In 1992 the MDM2 protein was shown to form a complex with p53 and inhibit p53-mediated transactivation. MDM2 is also an E3 ubiquitin ligase that promotes the rapid degradation of p53, as reported in 1997. Nutlins, reported in 2004, occupy the p53-binding pocket of MDM2 and activate the p53 pathway in cells and in vivo. Nutlin 3a is the active enantiomer of nutlin-3, and Nutlin 3b is a much weaker enantiomer used as a control. RG7112 and APG-115 are further MDM2 inhibitors, while MD-224 is a degrader that removes MDM2 protein. SJ 172550 targets the MDM2 relative MDM4 (also called MDMX).

7 Items

  • Nutlin-3
    Cat. No.
    A10657
    CAS No.
    548472-68-0

    Nutlin-3

    MDM2 antagonist nutlin-3 is a potent inducer of apoptosis.

    In stock View Details
    2 mg
    $45.00
    5 mg
    $60.00
    All 7 sizes
  • YH239-EE
    Cat. No.
    A14118
    CAS No.
    1364488-67-4

    YH239-EE

    YH239-EE is a potent p53-MDM2 antagonist and an apoptosis inducer.

    In stock View Details
    5 mg
    $55.00
    10 mg
    $80.00
    All 6 sizes
  • Nutlin 3b
    Cat. No.
    A11502
    CAS No.
    675576-97-3

    Nutlin 3b

    Synonyms: (+)-Nutlin-3

    Nutlin 3b is a p53/MDM2 antagonist or inhibitor with IC50 value of 13.6 uM, 150-fold less potent (+)-enantiomer of Nutlin-3 as in comparison with opposite (-)-enantiomer Nutlin-3a.

    In stock View Details
    1 mg
    $30.00
    2 mg
    $45.00
    All 8 sizes
  • MI-773
    Cat. No.
    A15440
    CAS No.
    1303607-60-4

    MI-773

    Synonyms: SAR405838

    MI-773 is an orally available MDM2 antagonist with Ki of 0.88 nM.

    In stock View Details
    1 mg
    $40.00
    2 mg
    $75.00
    All 8 sizes
  • (Rac)-Nutlin-3
    Cat. No.
    A33129
    CAS No.
    890090-75-2

    (Rac)-Nutlin-3

    Synonyms: (Rac)-Rebemadlin

    (Rac)-Nutlin-3 is a potent antagonist of the murine double minute protein 2 (MDM2), with an IC50 of 90 nM. This compound effectively disrupts the interaction between MDM2 and p53, leading to stabilization of the p53 protein. Additionally, (Rac)-Nutlin-3 promotes cell autophagy and apoptosis, making it a valuable tool for investigating the roles of MDM2 in TP53 wild-type ovarian carcinomas and other related cancer research applications.

    In stock View Details
    5 mg
    $40.00
    10 mg
    $65.00
    All 2 sizes
  • MI-219
    Cat. No.
    A53898
    CAS No.
    908027-55-4

    MI-219

    MI-219 is an MDM2 antagonist with a Ki of 13.3 μM, specifically designed to disrupt the interaction between MDM2 and p53. This compound effectively inhibits the proliferation of FSCCL cells, demonstrated by an IC50 of 2.5 μM. MI-219 is suitable for research applications focused on cancer biology, particularly in studies exploring pathways related to tumor suppression and the p53 signaling axis.

    In stock View Details
    25 mg
    $2,645.00
    50 mg
    $4,100.00
    All 3 sizes
  • Nutlin 1
    Cat. No.
    A53904
    CAS No.
    548472-58-8

    Nutlin 1

    Nutlin 1 is a potent MDM2 antagonist that reactivates the p53 pathway, playing a critical role in cell cycle regulation and apoptosis. With an IC50 of 0.26 μM, it effectively disrupts the MDM2-p53 interaction, promoting p53-mediated transcriptional activity. This compound is widely used in cancer research to explore the therapeutic potential of p53 reactivation in tumor cells.

    In stock View Details
    25 mg
    $1,275.00
    50 mg
    $1,625.00
    All 3 sizes

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