TNF-α

Cat. No.

A10522

CAS No.

191732-72-6

Lenalidomide (CC-5013)

Synonyms: Revlimid; CC-5013

Lenalidomide is a derivative of thalidomide. In vitro, lenalidomide has three main activities: direct anti-tumor effect, inhibition of the micro environment support for tumor cells, and immunomodulatory role. It induces tumor cell apoptosis directly and indirectly by inhibition of bone marrow stromal cell support, by anti-angiogenic and anti-osteoclastogenic effects, and by immunomodulatory activity.

Cat. No.

A19783

CAS No.

303997-35-5

R-7050

Synonyms: TNF-α Antagonist III

R-7050 (TNF-α Antagonist III) is a tumor necrosis factor receptor (TNFR) antagonist with greater selectivity toward TNFα.

Cat. No.

A25239

CAS No.

158983-23-4

VDX-111

VDX-111 is a necroptosis inducer that functions as an analog of vitamin D. It exerts cytotoxic effects in ovarian cancer cells by upregulating the RIPK1/RIPK3 pathway, leading to necroptotic cell death. Additionally, VDX-111 promotes cytokine expression and demonstrates significant antitumor activity in murine models, making it a valuable tool for cancer research focused on necroptosis.

Cat. No.

A25551

CAS No.

2243975-43-9

Hydrostatin-TL1

Synonyms: H-TL1

Hydrostatin-TL1 is a nine-amino-acid peptide that serves as a TNF-α antagonist. By competitively inhibiting the interaction between TNF-α and its receptor TNFR1, Hydrostatin-TL1 reduces TNF-α-mediated cytotoxicity and inflammation. This peptide is valuable for research into TNF-α-associated inflammatory diseases, including rheumatoid arthritis, osteoporosis, and inflammatory bowel disease (IBD).