Mitophagy

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  1. AMPK activator

    Acadesine is a selective activator of AMPK in both hepatocytes and adipocytes.

  2. Resveratrol has a wide spectrum of targets including cyclooxygenases(i.e. COX, IC50=1.1 μM), lipooxygenases???LOX, IC50=2.7 μM???, kinases, sirtuins and other proteins. It has anti-cancer, anti-inflammatory, blood-sugar-lowering and other beneficial cardiovascular effects.
  3. AMP-activated protein kinase (AMPK) activator

    Metformin is an AMP-activated protein kinase (AMPK) activator that improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose.
  4. AMP-activated protein kinase activator

    AICAR phosphate is an activator of AMP-activated protein kinase (AMPK).

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