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BET-IN-18

Catalog No.: A40463
BET Bromodomain Inhibitor
BET-IN-18 is a pan-BET bromodomain inhibitor targeting Brd4 and BrdT. It exhibits potent competitive inhibition of the binding of acetylated histone substrates as well as the known BET inhibitor (+)-JQ1, with IC50 values of 1.0 μM and 2.3 μM for Brd4 and BrdT, respectively. This compound is useful for investigating BET bromodomain functions in various biological contexts, particularly in the study of multiple myeloma.
BET-IN-18 874594-37-3 BET Bromodomain Inhibitor
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionBET-IN-18 is a pan-BET bromodomain inhibitor targeting Brd4 and BrdT. It exhibits potent competitive inhibition of the binding of acetylated histone substrates as well as the known BET inhibitor (+)-JQ1, with IC50 values of 1.0 μM and 2.3 μM for Brd4 and BrdT, respectively. This compound is useful for investigating BET bromodomain functions in various biological contexts, particularly in the study of multiple myeloma.
Product Information
Catalog NumA40463
FormulaC18H17N3O4
Molecular Weight339.35
CAS Number874594-37-3
SMILESO=C1OCC=2NC3=C(C(=O)NC(=O)N3CC)C(C4=CC=C(C=C4)C)C12
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