Inducible Expression & Protein Degradation Tags

Cat. No.

A12532

CAS No.

68392-35-8

(E/Z)-4-hydroxy Tamoxifen

Synonyms: Afimoxifene

(E/Z)-4-hydroxy Tamoxifen is the active metabolite of tamoxifen and a selective estrogen receptor (ER) modulator that is widely used in the therapeutic and chemopreventive treatment of breast cancer.

Cat. No.

A19833

CAS No.

914805-33-7

Shield-1

Shield-1 is a specific, cell-permeant and high-affinity ligand of FK506-binding protein-12 (FKBP), and reverses the instability by binding to mutated FKBP (mtFKBP), allowing conditional expression of mtFKBP-fused proteins.

Cat. No.

A20955

CAS No.

68047-06-3

4-Hydroxytamoxifen

Synonyms: (Z)-4-Hydroxytamoxifen; trans-4-Hydroxytamoxifen

4-Hydroxytamoxifen is a selective estrogen receptor modulator (SERM).

Cat. No.

A21127

CAS No.

195514-80-8

AP20187

Synonyms: B/B Homodimerizer

AP20187 (B/B Homodimerizer) is a cell-permeable ligand used to dimerize FK506-binding protein (FKBP) fusion proteins and initiate biological signaling cascades and gene expression or disrupt protein-protein interactions.

Cat. No.

A40246

CAS No.

168649-23-8

5-Ph-IAA

5-Ph-IAA is a ligand that specifically interacts with the auxin-inducible degron 2 (AID2) system, in conjunction with the OsTIR1 (F74G) mutant. This compound facilitates the rapid and efficient degradation of mAID-fused proteins, enabling the investigation of protein function in live cells. 5-Ph-IAA is particularly useful in studies related to protein turnover and regulation, offering insights into cellular processes such as tumor suppression. Its application in research enhances the understanding of protein dynamics in various biological contexts.

Cat. No.

A48825

CAS No.

233585-94-9

9-tert-Butyldoxycycline

9-tert-Butyldoxycycline acts as a Tet-On ligand, facilitating the control of gene expression in various biological models. It demonstrates immunomodulatory properties by influencing the polarization of polymorphonuclear neutrophils and mitigating inflammatory responses in ischemia-reperfusion injury scenarios. This compound is valuable for research applications involving gene regulation and the study of inflammatory processes.