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B-cell and hematologic antigen antibodies bind surface markers of B cells, plasma cells and myeloid leukemia cells. Rituximab, ofatumumab and obinutuzumab target CD20, while tafasitamab and inebilizumab bind CD19 on B cells. Daratumumab and isatuximab bind CD38, and elotuzumab binds signaling lymphocytic activation molecule F7 (SLAMF7) on myeloma cells. Belantamab targets B-cell maturation antigen (BCMA), and brentuximab targets CD30 on Hodgkin and anaplastic lymphoma cells. Further antibodies cover CD22, CD33, CD37, CD123, B-cell activating factor (BAFF) and leukocyte adhesion molecules.
The Anti-CD4 Antibody (OKT-4) is a chimeric mouse monoclonal antibody of the IgG2b, κ subclass, specifically designed to target human CD4. For accurate experimental control, it is recommended to use Mouse IgG2b kappa as the isotype control. This antibody is ideal for research applications requiring precise targeting of the CD4 protein.
The Anti-CD19 Antibody is a humanized monoclonal antibody expressed in Chinese Hamster Ovary (CHO) cells. It specifically targets CD19, a critical marker expressed on B cells, making it an essential tool for research in immunology and oncology. This antibody is comprised of a human IgG1 heavy chain and a human kappa light chain, with a predicted molecular weight of 145 kDa. For experimental control purposes, the appropriate isotype control is Human IgG1 kappa.
The Anti-CD11a/LFA-1α Antibody (R7-1) is a chimeric mouse IgG1 monoclonal antibody that specifically targets human CD11a/LFA-1α. For accurate isotype control in experimental procedures, it is recommended to use Mouse IgG1 kappa as the isotype control. This antibody is essential for studies focusing on immune cell adhesion and migration, making it a valuable tool for immunology research.
The Anti-CD19 Antibody (4G7) is a chimeric mouse IgG1 monoclonal antibody that specifically targets human CD19. This antibody serves as an essential tool for the identification and characterization of B-cells across various research applications. For isotype control, it is recommended to use Mouse IgG1 kappa, Isotype Control, to ensure specificity and accuracy in experiments involving this antibody.
Ibritumomab is a murine-derived monoclonal antibody produced in Chinese Hamster Ovary (CHO) cells, specifically targeting CD20 (MS4A1). This antibody is engineered with a human IgG1 heavy chain and a human kappa light chain, resulting in a predicted molecular weight of 145 kDa. For isotype control, Human IgG1 kappa, Isotype Control is recommended.
Rocduntatug is a chimeric monoclonal antibody targeting immunoglobulin kappa constant (IGKC), demonstrating notable anti-tumor activity. This compound is utilized in research applications focusing on cancer immunotherapy and the modulation of immune responses in tumor environments. It provides valuable insights into the efficacy of antibody-based treatments for malignancies expressing IGKC.
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