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Cardiometabolic & Bone

Cardiometabolic and bone antibodies target proteins that regulate lipid metabolism, muscle mass and bone remodeling. Evolocumab and alirocumab bind proprotein convertase subtilisin/kexin type 9 (PCSK9) and prevent degradation of the low-density lipoprotein (LDL) receptor. Evinacumab neutralizes angiopoietin-like protein 3 (ANGPTL3), an inhibitor of lipoprotein lipase. Denosumab binds receptor activator of nuclear factor kappa-B ligand (RANKL), and romosozumab binds sclerostin, a Wnt pathway inhibitor in bone. Further antibodies target myostatin and activin receptors, transthyretin, thyrotropin receptor and natriuretic peptide receptor 1.

Items 51-54 of 54

  • Golocdacimab — antibody illustration
    Cat. No.
    AT1405
    CAS No.
    2418540-63-1

    Golocdacimab

    Synonyms: MEDI6570

    Golocdacimab (MEDI6570) is a fully human monoclonal antibody that targets the lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1). This antibody is specifically designed for the investigation of its therapeutic potential in type 2 diabetes. Golocdacimab's specificity for LOX-1 makes it a valuable tool for research focused on understanding the role of this receptor in metabolic diseases.

    In stock View Details
    1 mg
    $240.00
    5 mg
    $624.00
    All 3 sizes
  • Orticumab — antibody illustration
    Cat. No.
    AT1544
    CAS No.
    1314241-10-5

    Orticumab

    Synonyms: MLDL1278A

    Orticumab (MLDL1278A) is a monoclonal antibody designed to target and inhibit oxidized or malondialdehyde-modified low-density lipoprotein (oxLDL). This antibody plays a crucial role in modulating autoimmune responses against oxLDL, which is implicated in the pathogenesis of atherosclerosis. Studies have demonstrated that Orticumab effectively improves atherosclerotic conditions in animal models. Additionally, it holds potential for research applications in exploring therapeutic avenues for psoriasis improvement. This antibody's specificity for oxLDL makes it a valuable tool in cardiovascular and autoimmune disease research.

    In stock View Details
    1 mg
    $400.00
    5 mg
    $1,200.00
    All 3 sizes
  • Resugosbart — antibody illustration
    Cat. No.
    AT1547
    CAS No.
    2647412-09-5

    Resugosbart

    Synonyms: SHR-1222

    Resugosbart is a human IgG4 κ monoclonal antibody targeting SOST. For optimal experimental control, it is recommended to use Human IgG4 (S228P) kappa as an isotype control. This antibody is designed for precise specificity to SOST, making it an essential tool for research focused on bone density regulation and osteoporosis.

    In stock View Details
    1 mg
    $450.00
    5 mg
    $1,400.00
    All 3 sizes
  • Trevogrumab — antibody illustration
    Cat. No.
    AT1561
    CAS No.
    1429201-24-0

    Trevogrumab

    Synonyms: REGN-1033

    Trevogrumab (REGN-1033) is a monoclonal antibody that specifically targets growth differentiation factor 8 (GDF8), also known as myostatin. This antibody is utilized in scientific studies focused on muscle wasting conditions such as disuse atrophy, chronic diseases, and alterations in dietary and nutrient intake. Trevogrumab is instrumental in elucidating the pathways and molecular mechanisms underlying muscle degeneration and recovery, making it a valuable tool in muscle biology research.

    In stock View Details
    1 mg
    $400.00
    5 mg
    $1,200.00
    All 3 sizes

Items 51-54 of 54

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