Cytochrome P450

Cat. No.

A10293

CAS No.

201530-41-8

Deferasirox

Synonyms: ICL-670; ICL-670A; CGP-72670

Deferasirox is a rationally-designed oral iron chelator, also a cytochrome P450 3A4 inducer, Cytochrome P450 2C8 inhibitor, and Cytochrome P450 1A2 inhibitor.

Cat. No.

A10625

CAS No.

480-41-1

Naringenin

Naringenin is a flavanone, a type of flavonoid, that is considered to have a bioactive effect on human health as antioxidant, free radical scavenger, anti-inflammatory, carbohydrate metabolism promoter, and immune system modulator.

Cat. No.

A20360

CAS No.

197913-15-8

CDD3506

CDD3506 is used for elevating high density lipoprotein cholesterol (HDL) by inducing hepatic cytochrome P450IIIA (CYP3A) activity.

Cat. No.

A20364

CAS No.

173865-33-3

CDD3505

CDD3505 is used for elevating high density lipoprotein cholesterol (HDL) by inducing hepatic cytochrome P450IIIA (CYP3A) activity.

Cat. No.

A20897

CAS No.

945531-77-1

Ezutromid

Synonyms: SMT C1100; BMN 195; VOX-C1100

Ezutromid is a novel Small utrophin's translation modulator with EC50 of 0.4 uM .

Cat. No.

A37721

CAS No.

1107-26-2

β-Apo-8'-carotenal

Synonyms: Apocarotenal

β-Apo-8'-carotenal is a potent inducer of CYP1A, acting through the aryl hydrocarbon receptor (AhR) pathway. This carotenoid has demonstrated the ability to induce DNA strand breaks and lipid peroxidation in cancer cells, making it a valuable tool for research into cancer biology and metabolic disorders. Its role as a provitamin A compound further emphasizes its potential applications in studies related to cellular metabolism and disease mechanisms.

Cat. No.

A43722

CAS No.

587-98-4

Acid Yellow 36

Synonyms: Metanil Yellow

Acid Yellow 36, an azo dye and pH indicator, primarily functions as a cytochrome P450 inducer. It exhibits a color change from red at pH 1.2 to yellow at pH 2.3, making it useful in various industrial applications, including leather, paper, and textiles. In the realm of biochemical research, Acid Yellow 36 is employed to induce specific isozymes of cytochrome P450 and various cytosolic enzymes, facilitating studies on enzyme regulation and metabolism.

Cat. No.

A64118

CAS No.

55673-89-7

1,2,3,4,7,8,9-Heptachlorodibenzofuran

Synonyms: 1,2,3,4,7,8,9-HpCDF

1,2,3,4,7,8,9-Heptachlorodibenzofuran is a potent inducer of CYP1A1 and CYP1B1 gene expression in human peripheral blood lymphocytes, promoting aryl hydrocarbon receptor repressor (AhRR) transcription. This compound enhances ethoxyresorufin-O-deethylase (EROD) activity, serving as a reliable biomarker for CYP1A1 activation. Additionally, it displays immunosuppressive properties by decreasing the number of splenic plaque-forming cells in mice while increasing aryl hydrocarbon hydroxylase (AHH) activity in liver microsomes. 1,2,3,4,7,8,9-Heptachlorodibenzofuran is valuable for research in immunology, metabolic disorders, and environmental toxicology.

Cat. No.

A69756

CAS No.

328087-38-3

Phortress

Synonyms: NSC 710305

Phortress is a potent cytochrome P450 inducer that specifically activates the aryl hydrocarbon receptor (AhR). By eliciting the transcription of CYP1A1, it demonstrates robust antitumor activity. This compound is valuable for research applications focused on drug metabolism, environmental toxicology, and the modulation of xenobiotic responses.

Cat. No.

A69795

CAS No.

119141-89-8

(R)-Esomeprazole

Synonyms: (R)-Omeprazole; (+)-Omeprazole

(R)-Esomeprazole is an orally active modulator of cytochrome P450 enzymes, specifically targeting CYP2C19, CYP3A4, and CYP2C9. This compound is instrumental in studying metabolic processes and drug interactions, particularly in the context of digestive system diseases. Its ability to influence metabolic pathways makes it a valuable tool in pharmacological research.

Cat. No.

A69808

CAS No.

15469-97-3

1-Tritylimidazole

1-Tritylimidazole is a potent inducer of cytochrome P450 enzymes, which play a critical role in drug metabolism and biotransformation. This compound enhances the enzymatic activity of various Cytochrome P450 isoforms, facilitating studies on drug interactions and metabolic pathways. Its applications extend to research in pharmacology, toxicology, and the development of therapeutic agents.

Cat. No.

A69846

CAS No.

98683-75-1

Ganolucidic acid B

Ganolucidic acid B is a triterpenoid compound that acts as an inducer of CYP3A4 via activation of human PXR (hPXR). This compound is significant in the study of metabolic pathways and drug metabolism, making it a valuable reagent for research into the regulation of cytochrome P450 enzymes. Ganolucidic acid B is useful for investigating the effects of metabolic inducers on pharmacokinetics and drug-drug interactions.

Cat. No.

A69900

CAS No.

72963-72-5

Imiprothrin

Imiprothrin is a potent inducer of CYP1A2, known for its significant effects on metallothionein 1a expression. This compound exhibits genotoxic and cytotoxic properties, evident through the initiation of detoxification responses in rat hepatocytes and the induction of chromosomal aberrations and micronucleus formation in bone marrow cells. Additionally, Imiprothrin prompts oxidative stress, resulting in lipid peroxidation and reactive oxygen species production, which can adversely affect liver and kidney functions. Though it inhibits weight gain and can lead to high mortality in female mice at elevated doses, it has not shown carcinogenicity in rat studies, with sensitive toxicity biomarkers including aspartate aminotransferase and total protein.

Cat. No.

A69946

CAS No.

288323-41-1

Thienyldecyl Isothiocyanate

Thienyldecyl Isothiocyanate serves as a cytochrome P450 modulator, demonstrating significant antiproliferative activity against cancer cells. This compound exerts its effects through the inhibition of cytochrome P450 enzymes and the induction of phase II detoxification enzymes, impacting xenobiotic metabolism. Thienyldecyl isothiocyanate is valuable for research in cancer biology and pharmacology, particularly in studies exploring enzyme modulation and its implications for drug metabolism and efficacy.

Cat. No.

A69951

CAS No.

20697-20-5

Methysticin

Synonyms: DL-Methysticin; (±)-Methystici

Methysticin is a kavalactone derived from kava extract, primarily acting as an inducer of CYP1A1. This compound is relevant in studies investigating metabolic enzyme modulation and its impact on drug metabolism. Additionally, it has potential implications in understanding the biochemical pathways associated with liver function and detoxification processes.