Foxo1 | Adooq Bioscience

Cat. No.: A15871

CAS No.: 836620-48-5

AS1842856

AS1842856 is a cell-permeable inhibitor that blocks the transcription activity of Foxo1 with IC50 of 33 nM. It could directly bind to the active Foxo1, but not the Ser256-phosphorylated form.

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5 mg

$40.00

10 mg

$60.00

All 7 sizes

Cat. No.: A39386

CAS No.: 1253226-93-5

AS1708727 is an orally active inhibitor of Foxo1, exhibiting EC50 values of 0.33 μM for glucose-6-phosphatase (G6Pase) and 0.59 μM for phosphoenolpyruvate carboxykinase (PEPCK). This compound plays a significant role in modulating metabolic pathways and is valuable for research into glucose homeostasis and metabolic disorders. AS1708727 can be utilized in studies investigating the therapeutic potential of targeting Foxo1 in various diseases, including diabetes and cancer.

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5 mg

$245.00

10 mg

$405.00

All 5 sizes

Cat. No.: A74862

CAS No.: 339103-05-8

JY-2

JY-2 is a selective inhibitor of the Forkhead box O1 (FoxO1) transcription factor, effectively inhibiting its transcriptional activity with an IC50 of 22 μM. This compound also exhibits moderate inhibitory effects on FoxO3a and FoxO4. JY-2 demonstrates notable anti-diabetic activity, making it a valuable tool for research related to metabolic disorders and the regulation of glucose homeostasis.

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5 mg

$40.00

10 mg

$65.00

All 5 sizes

Cat. No.: A74863

CAS No.: 2451093-95-9

FOXO1-IN-3

FOXO1-IN-3 is a selective inhibitor of FOXO1, a crucial transcription factor involved in glucose metabolism. This compound has demonstrated efficacy in reducing hepatic glucose production in murine models. Additionally, FOXO1-IN-3 enhances insulin sensitivity and improves glucose control in db/db mice, while not contributing to weight gain, making it a valuable tool for research on metabolic disorders and insulin resistance.

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5 mg

$295.00

10 mg

$545.00

All 5 sizes