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ICMT

ICMT inhibitors block isoprenylcysteine carboxyl methyltransferase, the last enzyme of protein prenyl processing. Many signaling proteins, including Ras GTPases, end in a cysteine-aliphatic-aliphatic-any amino acid (CAAX) motif that is prenylated, trimmed and then methylated. Methylation of the prenylated cysteine helps these proteins associate with cell membranes. In 1998 the mammalian methyltransferase was localized to the endoplasmic reticulum. Cysmethynil, reported in 2005 as a small-molecule ICMT inhibitor, mislocalized Ras and impaired epidermal growth factor signaling in cancer cells. UCM-1336, POP-3MB and ICMT-IN-1 are further inhibitors used to study Ras membrane targeting and cell growth.

Cat. No.

A30784

CAS No.

1621535-90-7

UCM-1336

UCM-1336 is a potent inhibitor of Isoprenylcysteine Carboxyl Methyltransferase (ICMT), exhibiting an IC50 of 2 μM. This compound effectively induces mislocalization of endogenous Ras, resulting in decreased Ras activation. UCM-1336 has shown the ability to trigger cell death through autophagy and apoptosis, making it a valuable tool for research in cancer biology and signal transduction pathways.

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5 mg

$35.00

10 mg

$55.00

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Cat. No.

A36790

CAS No.

1144114-27-1

POP-3MB

POP-3MB is an inhibitor of Isoprenylcysteine carboxyl methyltransferase (ICMT), with an IC50 value of 2.5 μM. It effectively alters the subcellular localization of K-Ras, leading to inhibition of Ras activation. Additionally, POP-3MB demonstrates the capacity to inhibit Erk phosphorylation, making it a valuable tool for research into Ras signaling pathways and related oncogenic processes.

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Cat. No.

A39379

CAS No.

851636-83-4

Cysmethynil

Cysmethynil is an inhibitor of Isoprenylcysteine carboxylmethyltransferase (Icmt) with an IC50 of 2.4 μM. It disrupts RAS membrane binding and interferes with EGF signal transduction, leading to cell cycle arrest in the G1 phase and the induction of autophagy. Cysmethynil effectively inhibits the proliferation of PC3 prostate cancer cells and demonstrates synergistic effects with chemotherapeutic agents such as Paclitaxel and Doxorubicin. This compound is applicable for research into solid tumors, including prostate cancer.

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1 mg

$30.00

5 mg

$65.00

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Cat. No.

A60907

CAS No.

1313603-22-3

ICMT-IN-1

ICMT-IN-1 is a selective inhibitor of isoprenylcysteine carboxyl methyltransferase (ICMT) with an IC50 of 0.0013 μM. This compound has been shown to effectively induce the accumulation of ICMT in the cytoplasm of HCT-116 cells. Additionally, ICMT-IN-1 exhibits significant antiproliferative activity against various cancer cell lines that express K-Ras and N-Ras, making it a valuable tool for research in cancer biology and therapeutic development.

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5 mg

$355.00

10 mg

$590.00

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Cat. No.

A60908

CAS No.

1313603-14-3

ICMT-IN-30

ICMT-IN-30 is a potent inhibitor of isoprenylcysteine carboxyl methyltransferase (ICMT), with an IC50 value of 0.27 μM. This compound is essential for studying the role of ICMT in various biological processes, including protein modification and signaling pathways. Its inhibition can be utilized in research focused on cancer, neurodegeneration, and other diseases associated with abnormal protein prenylation.

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Cat. No.

A60909

CAS No.

1313603-12-1

ICMT-IN-28

ICMT-IN-28 is a potent inhibitor of Isoprenylcysteine Carboxyl Methyltransferase (ICMT), exhibiting an IC50 value of 0.008 μM. This compound effectively disrupts the ICMT-mediated methylation of isoprenylated proteins, playing a critical role in cellular signaling pathways. ICMT-IN-28 is utilized in studies investigating the regulation of protein function and has potential applications in cancer research and other areas of cell biology.

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Cat. No.

A60910

CAS No.

1313602-90-2

ICMT-IN-52

ICMT-IN-52 is a specific inhibitor of isoprenylcysteine carboxyl methyltransferase (ICMT), exhibiting an IC50 value of 0.052 μM. This compound plays a crucial role in research on post-translational modifications and protein maturation related to oncogenesis and cellular signaling. Its ability to effectively inhibit ICMT makes it a valuable tool for studying the biological implications of ICMT activity in various disease models.

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Cat. No.

A60911

CAS No.

1313602-92-4

ICMT-IN-5

ICMT-IN-5 is a potent inhibitor of Isoprenylcysteine carboxyl methyltransferase (ICMT) with an IC50 of 0.3 μM. This compound modulates protein localization and activity through the inhibition of ICMT, making it valuable for studying signal transduction pathways and post-translational modifications. ICMT-IN-5 is suitable for research applications focused on cancer biology, neurobiology, and other fields where ICMT plays a critical role in regulating protein function.

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Cat. No.

A60912

CAS No.

1313602-85-5

ICMT-IN-34

ICMT-IN-34 is a potent inhibitor of Isoprenylcysteine carboxyl methyltransferase (ICMT) with an IC50 of 0.17 μM. This compound exhibits significant biological activity in the modulation of protein methylation, influencing various cellular processes. It is valuable for research applications aimed at elucidating the roles of ICMT in signal transduction and cancer biology.

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Cat. No.

A60913

CAS No.

1313602-89-9

ICMT-IN-51

ICMT-IN-51 is a potent inhibitor of isoprenylcysteine carboxyl methyltransferase (ICMT), with an IC50 value of 0.55 μM. This compound is essential for studying the role of ICMT in post-translational modifications of proteins, particularly in signaling pathways related to cancer and other diseases. Its utility in biochemical assays makes it a valuable tool for researchers investigating the therapeutic potential of ICMT modulation.

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Cat. No.

A60914

CAS No.

1313603-21-2

ICMT-IN-7

ICMT-IN-7 is a potent inhibitor of isoprenylcysteine methyltransferase (ICMT), with an IC50 of 0.015 μM. This compound effectively induces the accumulation of ICMT in the cytoplasm of HCT-116 cells and demonstrates significant inhibitory effects on the proliferation of various cancer cell lines that express K-Ras and N-Ras. ICMT-IN-7 is valuable for research applications targeting ICMT-related pathways in cancer biology.

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Cat. No.

A60915

CAS No.

1313602-75-3

ICMT-IN-6

ICMT-IN-6 is a potent inhibitor of isoprenylcysteine carboxyl methyltransferase (ICMT), with an IC50 value of 0.09 μM. This compound effectively disrupts ICMT activity, which plays a critical role in protein prenylation processes. ICMT-IN-6 is valuable for studying the biological implications of ICMT inhibition and its potential therapeutic applications in cancer and other diseases involving dysregulated protein prenylation.

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Cat. No.

A60916

CAS No.

371940-21-5

ICMT-IN-50

ICMT-IN-50 is a selective inhibitor of Isoprenylcysteine Carboxyl Methyltransferase (ICMT), with an IC50 value of 0.31 μM. This compound is utilized in research to investigate the role of ICMT in post-translational modifications and its impact on protein function and signaling pathways. Suitable for studies involving cancer biology and therapeutic development, ICMT-IN-50 provides a valuable tool for understanding ICMT's biological significance.

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Cat. No.

A60917

CAS No.

1313603-10-9

ICMT-IN-24

ICMT-IN-24 is a potent inhibitor of isoprenylcysteine carboxyl methyltransferase (ICMT) with an IC50 of 0.19 μM. This compound is utilized in research to explore the role of ICMT in post-translational modifications and its implications in various cellular processes. Its ability to inhibit ICMT makes it a valuable tool for studying protein activity and signaling pathways related to cancer and other diseases.

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Cat. No.

A60918

CAS No.

1313602-98-0

ICMT-IN-15

ICMT-IN-15 is a selective inhibitor of isoprenylcysteine carboxyl methyltransferase (ICMT), with an IC50 value of 0.032 μM. By blocking the activity of ICMT, this compound disrupts post-translational modifications of proteins involved in signaling pathways. ICMT-IN-15 is utilized in research focused on understanding the role of protein methylation in cellular processes and disease mechanisms, making it a valuable tool for studies in cancer, neurobiology, and other fields.

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Cat. No.

A60919

CAS No.

1313602-95-7

ICMT-IN-13

ICMT-IN-13 is a potent inhibitor of isoprenylcysteine carboxyl methyltransferase (ICMT), exhibiting an IC50 of 0.47 μM. This compound is crucial for studying the role of ICMT in post-translational modifications of proteins, particularly in oncogenic signaling pathways. Its application in chemical biology can provide insights into the regulation of protein function and potential therapeutic strategies targeting cancer progression.

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Cat. No.

A60920

CAS No.

1313602-71-9

ICMT-IN-46

ICMT-IN-46 is an inhibitor of isoprenylcysteine carboxyl methyltransferase (ICMT) with an IC50 of 0.556 μM. This compound plays a critical role in modulating protein prenylation processes, impacting various signaling pathways. It is suitable for research applications focused on cellular signaling, protein modification, and the investigation of diseases where ICMT activity is a key factor.

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Cat. No.

A60921

CAS No.

1313602-87-7

ICMT-IN-37

ICMT-IN-37 is a selective inhibitor of Isoprenylcysteine methyltransferase (ICMT), exhibiting an IC50 of 0.308 μM. This compound is instrumental for investigating the role of ICMT in various cellular processes, including protein localization and signaling pathways. Its application extends to studies on post-translational modifications and the functional implications of ICMT inhibition in cancer and other diseases.

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Cat. No.

A60922

CAS No.

1313603-11-0

ICMT-IN-27

ICMT-IN-27 is a selective inhibitor of isoprenylcysteine carboxyl methyltransferase (ICMT) with an IC50 value of 0.1 μM. This compound effectively disrupts the post-translational modification of proteins that rely on ICMT activity. It is primarily utilized in studies involving protein regulation, signal transduction, and cancer research, enabling scientists to explore the role of ICMT in various biological processes.

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Cat. No.

A60923

CAS No.

1313603-01-8

ICMT-IN-20

ICMT-IN-20 is a selective inhibitor of isoprenylcysteine carboxyl methyltransferase (ICMT), with an IC50 value of 0.682 μM. This compound is instrumental in the study of post-translational modifications in proteins, facilitating research into their role in various cellular processes. ICMT-IN-20 is applicable in investigations of signal transduction pathways and may contribute to the understanding of certain diseases where ICMT activity is disrupted.

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Cat. No.

A60924

CAS No.

1313602-69-5

ICMT-IN-44

ICMT-IN-44 is a selective inhibitor of isopeptidase cyseel methyltransferase (ICMT) with an IC50 value of 0.167 μM. This compound is designed to disrupt the methylation of cyseel proteins, thereby influencing post-translational modifications and cellular signaling pathways. ICMT-IN-44 is valuable in biochemical research for studying the role of ICMT in various physiological and pathological processes, making it a useful tool in drug discovery and development.

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Cat. No.

A60925

CAS No.

1313602-86-6

ICMT-IN-36

ICMT-IN-36 is a specific inhibitor of Isoprenylcysteine carboxyl methyltransferase (ICMT), showing an IC50 value of 0.181 μM. This compound is valuable for researchers investigating ICMT’s role in protein modification and its implications in cancer and other diseases. Its applications include studying protein stability and signaling pathways related to post-translational modifications.

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Cat. No.

A60926

CAS No.

1313603-25-6

ICMT-IN-12

ICMT-IN-12 is a selective inhibitor of isoprenylcysteine carboxymethyltransferase (ICMT) with an IC50 value of 0.42 μM. This compound demonstrates important biological activity by blocking ICMT-mediated post-translational modifications, which play a crucial role in protein function and stability. ICMT-IN-12 is applicable in studies focusing on signaling pathways and cellular processes influenced by protein prenylation, making it a valuable tool for research in cancer biology and therapeutic development.

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Cat. No.

A60927

CAS No.

1313602-76-4

ICMT-IN-8

ICMT-IN-8 is a potent inhibitor of Isoprenylcysteine carboxyl methyltransferase (ICMT), exhibiting an IC50 value of 0.652 μM. This compound is primarily utilized in research applications focusing on protein prenylation and related signaling pathways. Investigating ICMT's role can provide insights into its potential implications in cancer and other diseases linked to dysregulated protein modification.

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Cat. No.

A60928

CAS No.

1310740-69-2

ICMT-IN-21

ICMT-IN-21 is a potent inhibitor of isoprenylcysteine O-methyltransferase (ICMT), with an IC50 value of 8.8 μM. This compound features a sulfonamide-modified farnesyl cysteine structure, with key farnesyl and carboxylic acid motifs critical for its inhibitory activity. ICMT-IN-21 is valuable for investigating the role of ICMT in post-translational modifications and cellular signaling processes, providing insights into potential therapeutic interventions.

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