CN427 is a quinazoline-based compound that selectively inhibits the bromodomain-containing protein 4 (BRD4) with a Kd of 66 nM. This inhibition disrupts the interaction between BRD4 and acetylated histones, which can lead to altered transcriptional regulation. CN427 is primarily applicable in leukemia research, providing insights into epigenetic modulation and potential therapeutic strategies in this malignancy.
CN427 is a quinazoline-based compound that selectively inhibits the bromodomain-containing protein 4 (BRD4) with a Kd of 66 nM. This inhibition disrupts the interaction between BRD4 and acetylated histones, which can lead to altered transcriptional regulation. CN427 is primarily applicable in leukemia research, providing insights into epigenetic modulation and potential therapeutic strategies in this malignancy.
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