CP-316819 is a potent inhibitor of glycogen phosphorylase (GPase), demonstrating significant antihyperglycemic activity with IC50 values of 17 nM and 34 nM against human skeletal muscle glycogen phosphorylase (huSMGPa) and liver glycogen phosphorylase (huLGPa), respectively. This compound promotes glycogen accumulation under normoglycemic conditions while allowing glycogen utilization during low glucose availability. Additionally, CP-316819 has been shown to prevent neuronal cell death and sustain brain electrical activity, making it a valuable tool for research into metabolic regulation and neuroprotection.
CP-316819 is a potent inhibitor of glycogen phosphorylase (GPase), demonstrating significant antihyperglycemic activity with IC50 values of 17 nM and 34 nM against human skeletal muscle glycogen phosphorylase (huSMGPa) and liver glycogen phosphorylase (huLGPa), respectively. This compound promotes glycogen accumulation under normoglycemic conditions while allowing glycogen utilization during low glucose availability. Additionally, CP-316819 has been shown to prevent neuronal cell death and sustain brain electrical activity, making it a valuable tool for research into metabolic regulation and neuroprotection.
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