TK-112690 is a selective inhibitor of uridine phosphorylase 1 (UPP1). It demonstrates inhibitory effects on murine small intestinal uridine phosphorylase with an IC50 of 12.5 μM and on human small intestinal UPP1 with an IC50 of 20.0 μM in vitro. By increasing plasma uridine concentration in mice, TK-112690 can be utilized to explore therapeutic avenues in cancer research and pulmonary fibrosis studies.
TK-112690 is a selective inhibitor of uridine phosphorylase 1 (UPP1). It demonstrates inhibitory effects on murine small intestinal uridine phosphorylase with an IC50 of 12.5 μM and on human small intestinal UPP1 with an IC50 of 20.0 μM in vitro. By increasing plasma uridine concentration in mice, TK-112690 can be utilized to explore therapeutic avenues in cancer research and pulmonary fibrosis studies.
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