Endonuclease | Adooq Bioscience

Cat. No.: A39456

CAS No.: 1424353-63-8

PNR-3-80

PNR-3-80 is a selective inhibitor of endonuclease G (ENDOG), exhibiting an IC50 value of 0.67 μM. By non-competitively binding to the ENDOG-substrate complex, PNR-3-80 effectively suppresses ENDOG's enzymatic activity. This compound has demonstrated the ability to mitigate cell death induced by chemotherapeutic agents such as Cisplatin and Docetaxel, while also inhibiting DNA damage and autophagy triggered by Etoposide. PNR-3-80 is valuable for research focused on cellular injury and the underlying mechanisms of chemoresistance.

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5 mg

$410.00

10 mg

$670.00

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Cat. No.: A54075

CAS No.: 824983-91-7

FEN1-IN-1

FEN1-IN-1 is a selective inhibitor of flap endonuclease 1 (FEN1), demonstrating significant antitumor activity. It functions by binding to the active site of FEN1, with inhibition partially facilitated by the coordination of Mg2+ ions. This compound triggers a DNA damage response, subsequently activating the ATM checkpoint signaling pathway, leading to the phosphorylation of histone H2AX and the ubiquitination of FANCD2 in mammalian cells. FEN1-IN-1 is a valuable tool for cancer research, particularly in studies focused on DNA repair mechanisms and tumor progression.

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1 mg

$20.00

2 mg

$25.00

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Cat. No.: A54620

CAS No.: 1558598-41-6

PFM01

PFM01 is a N-alkylated Mirin derivative that functions as an inhibitor of the MRE11 endonuclease. This compound effectively modulates the repair of double-strand breaks (DSBR) by influencing the choice between nonhomologous end-joining (NHEJ) and homologous recombination (HR) pathways. PFM01 is valuable for studies examining DNA repair mechanisms and therapeutic approaches targeting DNA damage response pathways.

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$20.00

10 mg

$30.00

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Cat. No.: A54624

CAS No.: 2098776-03-3

FEN1-IN-SC13

FEN1-IN-SC13 is a selective inhibitor of DNA fragmentation endonuclease 1 (FEN1), pivotal in DNA replication and repair processes. This compound demonstrates significant antitumor activity by disrupting the normal functioning of FEN1, leading to impaired DNA metabolism in vitro and within cellular environments. It serves as a valuable tool for researchers investigating the mechanisms of DNA damage response and the development of cancer therapeutics.

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1 mg

$45.00

5 mg

$105.00

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Cat. No.: A54627

CAS No.: 2379405-61-3

MU147

MU147 is a potent inhibitor of the MRE11 nuclease, functioning as a valuable chemical probe in cancer research. It exhibits significant anticancer activity by inducing lethality in Ehrlich ascites tumor cells both in vitro and in vivo. Additionally, MU147 disrupts the double-strand break repair mechanism dependent on MRE11 activity while preserving ATM activation. This compound also hinders the degradation of nascent strands during stalled replication, particularly affecting cells deficient in BRCA2.

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5 mg

$165.00

10 mg

$270.00

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Cat. No.: A54628

CAS No.: 2379671-78-8

MU1409

MU1409 is a selective inhibitor of the MRE11 nuclease, exhibiting an IC50 of 12.1 μM. Additionally, MU1409 inhibits FEN1 and EXO1, with IC50 values of 24.2 μM and 176.4 μM, respectively. This compound plays a crucial role in modulating DNA repair mechanisms, particularly in BRCA2-deficient cells, by preventing the degradation of stalled replication forks. MU1409 shows promise for research focused on BRCA2 mutation-related cancers and the mechanisms of genomic instability.

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5 mg

$330.00

10 mg

$520.00

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Cat. No.: A64653

CAS No.: 1995893-58-7

FEN1-IN-4

FEN1-IN-4 is a selective inhibitor of human flap endonuclease-1 (hFEN1), targeting the enzyme's crucial role in DNA replication and repair. This compound demonstrates significant biological activity by obstructing hFEN1's enzymatic function, which is essential for maintaining genomic stability. FEN1-IN-4 is valuable for research applications in cancer biology and the study of DNA repair mechanisms, providing insights into potential therapeutic strategies for related diseases.

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1 mg

$30.00

2 mg

$45.00

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Cat. No.: A64655

CAS No.: 824983-94-0

FEN1-IN-2

FEN1-IN-2 is a selective inhibitor of flap endonuclease 1 (FEN1), demonstrating an IC50 of 3 nM. It exhibits significantly lower activity against XPG, with an IC50 of 226 nM. This compound is valuable for investigating FEN1's role in DNA repair processes and its potential implications in cancer research. Researchers can utilize FEN1-IN-2 to study mechanisms of cellular response to DNA damage and identify therapeutic strategies targeting FEN1-related pathways.

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2 mg

$80.00

5 mg

$130.00

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Cat. No.: A64659

CAS No.: 824983-90-6

FEN1-IN-7

FEN1-IN-7 is a selective inhibitor of Flap endonuclease-1 (FEN1), with an IC50 of 18 nM, crucial for DNA repair in mammalian cells. In addition, it exhibits activity against xeroderma pigmentosum G (XPG) with an IC50 of 3.04 μM. FEN1-IN-7 enhances the sensitivity of cancer cells to DNA alkylating and methylating agents, making it a valuable tool for research in cancer therapy and DNA damage response mechanisms.

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Cat. No.: A64660

CAS No.: 824983-93-9

FEN1-IN-5

FEN1-IN-5 is a potent inhibitor of Flap endonuclease-1 (FEN1) with an IC50 of 12 nM. FEN1 plays a crucial role in DNA repair processes, particularly in the maturation of Okazaki fragments during DNA replication. This compound serves as a valuable tool in research applications aimed at dissecting the mechanisms of DNA repair and exploring potential therapeutic targets for conditions associated with FEN1 dysfunction.

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Cat. No.: A64661

CAS No.: 824983-84-8

FEN1-IN-6

FEN1-IN-6 is a potent inhibitor of Flap endonuclease-1 (FEN1), with an IC50 of 10 nM. This compound plays a significant role in cellular mechanisms for DNA damage repair, enhancing research into DNA repair processes. Additionally, FEN1-IN-6 exhibits activity against the related endonuclease xeroderma pigmentosum G (XPG) with an IC50 of 23 nM, making it a valuable tool for studying nucleic acid metabolism and repair pathways.

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Cat. No.: A64662

CAS No.: 2109805-87-8

FEN1-IN-3

FEN1-IN-3 is a selective inhibitor of human flap endonuclease-1 (hFEN1), a crucial enzyme involved in DNA replication and repair. With an EC50 value of 6.8 µM, FEN1-IN-3 effectively stabilizes hFEN1, making it a valuable tool for studying DNA metabolic processes. This compound is suitable for research applications focused on cancer biology, gene expression regulation, and the exploration of therapeutic strategies targeting DNA repair mechanisms.

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5 mg

$25.00

10 mg

$45.00

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Cat. No.: A64670

CAS No.: 3098173-31-7

FEN1-IN-8

FEN1-IN-8 is a selective inhibitor of flap endonuclease 1 (FEN1), exhibiting an IC50 of less than 100 nM for FEN1 and a range of 100 nM to 1 μM for exonuclease 1 (EXO1). This compound serves as a valuable tool for studying the role of FEN1 in colorectal and gastric cancers, providing insights into tumor biology and potential therapeutic pathways. FEN1-IN-8 is suitable for research applications focused on understanding DNA repair mechanisms and their implications in cancer progression.

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