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Dot1L-IN-5

Catalog No.: A26765
DOT1L Inhibitor
Dot1L-IN-5 is a highly potent inhibitor of the telomeric silencing 1-like protein (DOT1L), exhibiting an IC50 of 0.17 nM. This compound is essential for investigating the role of DOT1L in epigenetic regulation and its implications in various cancers and developmental disorders. It serves as a valuable tool for researchers exploring the therapeutic potential of DOT1L modulation in disease models.
Dot1L-IN-5 2565705-03-3 DOT1L Inhibitor
Grouped product items
Size Price Stock Qty
5mg
$330.00
In stock
10mg
$570.00
In stock
25mg
$1,025.00
In stock
50mg
$1,630.00
In stock
100mg
$2,400.00
In stock
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Free Delivery on orders over $500
Research use only. We do not sell to patients.
Data Sheet SDS

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionDot1L-IN-5 is a highly potent inhibitor of the telomeric silencing 1-like protein (DOT1L), exhibiting an IC50 of 0.17 nM. This compound is essential for investigating the role of DOT1L in epigenetic regulation and its implications in various cancers and developmental disorders. It serves as a valuable tool for researchers exploring the therapeutic potential of DOT1L modulation in disease models.
Product Information
Catalog NumA26765
FormulaC23H19ClF2N8O5S
Molecular Weight592.96
CAS Number2565705-03-3
SMILESO=S(C1=CC=C(N[C@H](C2=NC=CC=C2Cl)C3=C4OC(F)(F)OC4=CC=C3)C(NC5=NC(N)=NC(OC)=N5)=C1)(N)=O
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

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Epigenetics > Histone Methyltransferase