Dot1L-IN-7 is a potent inhibitor of DOT1L (disruptor of telomeric silencing 1-like protein) with an IC50 of 1.0 μM. This compound selectively induces cytotoxic effects in Mixed Lineage Leukemia (MLL)-AF9 cells while leaving E2A-HLF cells unaffected. It serves as a valuable tool for studying the roles of DOT1L in leukemogenesis and evaluating potential therapeutic strategies for MLL.
Dot1L-IN-7 is a potent inhibitor of DOT1L (disruptor of telomeric silencing 1-like protein) with an IC50 of 1.0 μM. This compound selectively induces cytotoxic effects in Mixed Lineage Leukemia (MLL)-AF9 cells while leaving E2A-HLF cells unaffected. It serves as a valuable tool for studying the roles of DOT1L in leukemogenesis and evaluating potential therapeutic strategies for MLL.
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