DS-437 is a dual inhibitor of PRMT5 and PRMT7, with IC₅₀ values of 6 μM for both enzymes. It exhibits high selectivity over 29 other human methyltransferases, including protein, DNA, and RNA methyltransferases. DS-437 functions as a S-adenosylmethionine (SAM)-competitive inhibitor of PRMT5 and also inhibits DNMT3A and DNMT3B with IC₅₀ values of 52 μM and 62 μM, respectively. Additionally, DS-437 inhibits the methylation of FOXP3, making it a useful tool for studying epigenetic regulation and immune modulation.
DS-437 is a dual inhibitor of PRMT5 and PRMT7, with IC₅₀ values of 6 μM for both enzymes. It exhibits high selectivity over 29 other human methyltransferases, including protein, DNA, and RNA methyltransferases. DS-437 functions as a S-adenosylmethionine (SAM)-competitive inhibitor of PRMT5 and also inhibits DNMT3A and DNMT3B with IC₅₀ values of 52 μM and 62 μM, respectively. Additionally, DS-437 inhibits the methylation of FOXP3, making it a useful tool for studying epigenetic regulation and immune modulation.
Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
