Glucocorticoid Receptors

Glucocorticoid receptor agonists and antagonists act on the nuclear receptor activated by cortisol. The glucocorticoid receptor (GR) is a ligand-activated transcription factor that controls genes for metabolism, stress responses and inflammation. Cloning of the human GR complementary DNA in 1985 placed it in the steroid hormone receptor family. A 2002 crystal structure of its ligand-binding domain with dexamethasone revealed a new dimer interface and mode of coactivator binding. The category covers the endogenous hormone hydrocortisone (cortisol) and synthetic agonists such as dexamethasone, budesonide and fluticasone propionate. The antagonist mifepristone, by contrast, blocks both glucocorticoid and progesterone receptors. Some entries act mainly on other targets, such as the progestin levonorgestrel and GANT61, an antagonist of glioma-associated oncogene (GLI) transcription factors.

5 Items

  • Glucocorticoid receptor activator 1
    Cat. No.
    A24886

    Glucocorticoid receptor activator 1

    Glucocorticoid Receptor Activator 1 is a phenyl aziridine precursor that selectively activates the glucocorticoid receptor (GR). This compound down-regulates TNF-induced pro-inflammatory gene expression, making it a valuable tool for studying inflammation mechanisms. Its role in modulating inflammatory responses positions it as an important reagent for research in various inflammatory conditions.

    100 mg
    $20.00
    250 mg
    $30.00
    All 4 sizes
  • Flunisolide hemihydrate
    Cat. No.
    A32630

    Flunisolide hemihydrate

    Flunisolide hemihydrate is an orally active glucocorticoid receptor activator with potent anti-inflammatory properties. It induces eosinophil apoptosis, making it a valuable tool for researchers investigating asthma, rhinitis, and various inflammatory conditions. Its mechanism of action supports studies focused on the modulation of inflammatory pathways and the therapeutic applications of corticosteroids in respiratory diseases.

    25 mg
    $1,275.00
    50 mg
    $1,625.00
    All 3 sizes
  • Glucocorticoids receptor agonist 3
    Cat. No.
    A64766

    Glucocorticoids receptor agonist 3

    Glucocorticoids Receptor Agonist 3 is a potent activator of the glucocorticoid receptor, functioning by modulating inflammation and metabolic processes through receptor activation. This compound is primarily utilized in research focused on obesity, diabetes, and inflammatory diseases, providing insights into the underlying mechanisms and potential therapeutic strategies for these conditions.

    25 mg
    $1,275.00
    All 1 sizes
  • Deacylcortivazol
    Cat. No.
    A64801

    Deacylcortivazol

    Deacylcortivazol is a potent glucocorticoid receptor (GR) activator. It exhibits significant biological activity by modulating GR signaling pathways, which are crucial for various physiological processes, including inflammation and metabolism. This compound is primarily used in research applications that investigate the role of glucocorticoids in cellular responses and their therapeutic potential in inflammatory diseases and stress responses.

    Out of stock

    All 3 sizes
  • Clobetasone 17-Propionate
    Cat. No.
    A64814

    Clobetasone 17-Propionate

    Clobetasone 17-Propionate is a potent glucocorticoid receptor activator. It exhibits anti-inflammatory and immunosuppressive properties, making it valuable in the treatment of various dermatological conditions such as eczema and psoriasis. This compound is widely utilized in research applications focused on studying corticosteroid signaling pathways and their effects on immune responses and skin disorders.

    1 mg
    $105.00
    5 mg
    $325.00
    All 2 sizes

5 Items

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