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Progesterone Receptors

Progesterone receptor agonists and antagonists act on a nuclear receptor for progesterone. The progesterone receptor (PR) occurs as two isoforms, PR-A and PR-B, which are transcribed from two estrogen-regulated promoters of one gene. Work in mice assigned a defined subset of reproductive responses to progesterone to the PR-B isoform alone. Medroxyprogesterone acetate and drospirenone are synthetic progestins that activate the receptor in cell and tissue models. Lonaprisan blocks receptor activation, while ulipristal acetate behaves as a selective receptor modulator with mixed agonist and antagonist behavior. Tamoxifen citrate is listed here as well, since steroid receptor crosstalk is often studied together with the related Estrogen Receptors category.

2 Items

  • Cridanimod
    Cat. No.
    A64844
    CAS No.
    38609-97-1

    Cridanimod

    Cridanimod is a potent activator of the progesterone receptor (PR) that functions primarily through the induction of interferon-alpha (IFNα) and interferon-beta (IFNβ) expression. As a small-molecule immunomodulator and interferon inducer, it plays a crucial role in modulating immune responses. Cridanimod is primarily utilized in research applications focusing on reproductive biology, immunology, and the therapeutic potential of interferon-mediated pathways.

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    10 mg
    $20.00
    25 mg
    $35.00
    All 6 sizes
  • CPAG-1
    Cat. No.
    A85405
    CAS No.
    2094991-62-3

    CPAG-1

    CPAG-1 is a small-molecule activator of the progesterone receptor membrane component 2 (PGRMC2). It enhances mitochondrial heme delivery to the nucleus, promoting the activation of genes associated with thermogenesis in brown adipose tissue, such as Ucp1 and Pgc-1α, while also decreasing lipid accumulation. Additionally, CPAG-1 has demonstrated the potential to lower fasting blood sugar and insulin levels, and improve glucose tolerance and insulin sensitivity. This compound is valuable for researching the mechanisms underlying type 2 diabetes.

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    Out of stock

    All 3 sizes

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