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5-alpha-reductase

5-alpha-reductase inhibitors block the enzymes that convert testosterone into dihydrotestosterone (DHT). Steroid 5α-reductases are membrane-bound enzymes that use NADPH (reduced nicotinamide adenine dinucleotide phosphate) to reduce a double bond in the steroid A ring. Human and rat forms of the enzyme were cloned and characterized in 1990. A second isozyme, steroid 5α-reductase 2 (SRD5A2), was reported in 1991, when deletions of its gene were found in male pseudohermaphroditism. Inhibitors are used to study androgen action in the prostate, skin and hair follicles. Finasteride and epristeride are steroidal inhibitors, and dutasteride blocks both isozymes. Plant-derived inhibitors in the category include β-sitosterol and the prenylated flavonoid Kushenol Q.

1 Item

  • Glutamic acid-alanine-glycine mixture
    Cat. No.
    A69138
    CAS No.
    8058-79-5

    Glutamic acid-alanine-glycine mixture

    Glutamic acid-alanine-glycine mixture serves as an activator of testosterone 5α-reductase, enhancing its enzymatic activity and promoting prostate function through elevated free amino acid levels. This compound demonstrates a complex interaction with testosterone and estradiol, as it inhibits 5α-reductase activity in combination, leading to decreased free amino acids. The mixture is valuable for research into prostate health and endocrine disorders, providing insights into regulatory mechanisms of steroid metabolism.

    In stock View Details
    25 mg
    $1,275.00
    50 mg
    $1,625.00
    All 3 sizes

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