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ROR

ROR modulators target retinoic acid receptor-related orphan receptors (RORs), a family of nuclear receptors. The family has three members, RORĪ±, RORĪ² and RORĪ³, which bind ROR response elements in target genes and are active without an added ligand. RORĪ± contributes to circadian clock regulation, and the immune isoform RORĪ³t directs the differentiation of interleukin-17 (IL-17)-producing T helper (Th17) cells. In 2011 the synthetic RORĪ±/Ī³ ligand SR1001 was shown to suppress Th17 differentiation and autoimmunity in mice. SR-2211 and XY101 act on RORĪ³, whereas SR3335 is selective for RORĪ±. SR1078 is used as an agonist of RORĪ± and RORĪ³ in studies of target gene expression. Related receptors without well-defined ligands are listed under Orphan Nuclear Receptor.

2 Items

  • 7ß,27-Dihydroxycholesterol
    Cat. No.
    A77566
    CAS No.
    240129-43-5

    7Ɵ,27-Dihydroxycholesterol

    Synonyms: 7Ī²; 27-OHC

    7Ɵ,27-Dihydroxycholesterol (7Ī², 27-OHC) is a selective activator of RORĪ³t, exhibiting a Ki of 120 nM. This compound plays a crucial role in promoting the differentiation of CD4+ Th17 cells in both mouse and human models. Additionally, 7Ɵ,27-Dihydroxycholesterol enhances IL-17 production through a CYP27A1-dependent pathway, making it valuable for studies focused on immune response and related signaling pathways.

    In stock View Details
    0.5 mg
    $345.00
    1 mg
    $470.00
    All 2 sizes
  • RORγt agonist 3
    Cat. No.
    A77573
    CAS No.
    2664106-24-3

    RORĪ³t agonist 3

    RORĪ³t Agonist 3 is a potent activator of RORĪ³t, crucial for the differentiation of Th17 cells. This compound enhances the production of pro-inflammatory cytokines, thereby boosting lymphocyte cytotoxicity. Additionally, RORĪ³t Agonist 3 suppresses the generation of regulatory T cells, which may lead to an augmented immune response, making it valuable for research into immune modulation and inflammatory diseases.

    In stock View Details
    5 mg
    $410.00
    10 mg
    $715.00
    All 5 sizes

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