Complement System

Cat. No.

A16946

CAS No.

514814-49-4

PMX-205

PMX-205 is a cyclic hexapeptide that acts as a potent antagonist of C5a receptor (C5aR; IC50 = 31 nM).

Cat. No.

A21347

CAS No.

1140525-25-2

SB290157 trifluoroacetate

Synonyms: SB 290157

SB290157 trifluoroacetate is a potent and selective C3a receptor antagonist with an IC50 of 200 nM.

Cat. No.

A24350

CAS No.

2411440-41-8

JR14a

JR14a is a potent thiophene-based antagonist of the human complement C3a receptor (C3aR). It exhibits high selectivity for C3aR over the C5a receptor and effectively suppresses C3aR-mediated inflammatory responses. JR14a is a valuable tool for studying the role of C3aR in immune regulation and inflammation-related diseases.

Cat. No.

A24465

CAS No.

125228-51-5

L-156602

Synonyms: Antibiotic L 156602; PD 124966

L-156602 is a C5a receptor antagonist that inhibits inflammation and blocks the migration of monocytes and neutrophils to sites of infiltration in mouse inflammatory models. It also suppresses the efferent phase of delayed-type hypersensitivity (DTH).

Cat. No.

A24469

CAS No.

1092847-21-6

CP-447697

CP-447697 is a lipophilic C5a receptor antagonist with an IC₅₀ value of 31 nM. It is suitable for research related to inflammation and complement system modulation.

Cat. No.

A24472

CAS No.

1434873-26-3

BR103

BR103 is a C3a receptor (C3aR)-specific small molecule ligand. It is useful for measuring ligand affinity to G protein-coupled receptors (GPCRs) through saturation and competitive binding assays.

Cat. No.

A24479

CAS No.

405098-33-1

W-54011

W-54011 is a potent, orally active, non-peptide antagonist of the C5a receptor. It inhibits the binding of \[¹²⁵I]-labeled C5a to human neutrophils with a Kᵢ of 2.2 nM. W-54011 also suppresses C5a-induced intracellular Ca²⁺ mobilization, chemotaxis, and reactive oxygen species (ROS) generation in human neutrophils, with IC₅₀ values of 3.1 nM, 2.7 nM, and 1.6 nM, respectively.

Cat. No.

A24484

CAS No.

1254036-23-1

JPE-1375

JPE-1375 is a complement C5a receptor 1 (C5aR1) antagonist that effectively inhibits polymorphonuclear leukocyte mobilization with an EC₅₀ of 6.9 µM and reduces TNF levels with an EC₅₀ of 4.5 µM in mice. It is suitable for research in autoimmune and inflammatory diseases.

Cat. No.

A35207

CAS No.

2365325-67-1

C5aR1 antagonist 1

C5aR1 antagonist 1 is a selective antagonist of the complement component 5a receptor 1 (C5aR1) with notable oral bioavailability. It exhibits potent activity in both DISCO and migration assays, demonstrating IC50 values of 38 nM and 17 nM, respectively. This compound is suitable for investigating the roles of C5aR1 in acute and chronic inflammatory diseases, facilitating research into potential therapeutic interventions.

Cat. No.

A35216

CAS No.

2489430-53-5

Izicopan

Synonyms: INF056

Izicopan (INF056) is a potent antagonist of the complement factor C5a receptor, effectively disrupting C5a-mediated signaling pathways. It demonstrates significant inhibition of C5a-induced calcium mobilization, with an IC50 in the range of 10-100 nM. This compound is valuable for research into inflammatory responses and immune modulation, making it a crucial tool for studies focused on autoimmune diseases and related therapeutic interventions.

Cat. No.

A35227

CAS No.

2365161-92-6

C5aR1 antagonist 2

C5aR1 antagonist 2 is an orally active antagonist targeting the C5a receptor 1 (C5aR1). It effectively inhibits C5a-induced neutrophil recruitment, demonstrated by IC50 values of 21 nM in DISCO assays and 3 nM in migration assays. This compound is suitable for research into acute and chronic inflammatory diseases, providing a valuable tool for understanding the role of C5aR1 in inflammatory processes.

Cat. No.

A35232

CAS No.

2363082-87-3

ACT-1014-6470

ACT-1014-6470 is a selective and reversible antagonist of the C5a receptor 1 (C5aR1). It exhibits strong inhibitory activity against C5aR1 activation, making it a valuable tool for investigating inflammatory processes. This compound is suitable for research applications related to various inflammatory diseases, providing insights into the role of C5aR1 in immune responses.