NOD-like Receptor (NLR)

Cat. No.

A14451

CAS No.

52659-56-0

Kirenol

Kirenol is a diterpenoid compound, an orally active apoptosis inducer and signaling pathway regulator, with a Kd value of 5.47 μM against the target CK2. Kirenol promotes the cleavage of Bid into tBid, regulates the protein levels/phosphorylation of Bax, Bcl-2, p53 and p21, and induces caspase-independent apoptosis, S-phase cell cycle arrest, ROS accumulation and cytotoxicity in cancer cells. Kirenol activates the CK2/AKT and AMPK-mTOR-ULK1 pathways, inhibits the signaling of NF-κB, TGF-β/Smads and NLRP3 inflammasome, and regulates the GSK3β, BMP and Wnt/β-catenin pathways. Kirenol induces autophagy, mitophagy and osteoblast differentiation, promotes mitochondrial fusion, and exerts antioxidant, anti-inflammatory, antifibrotic, renoprotective, cardioprotective, neuroprotective and analgesic effects. Kirenol is applicable to research related to chronic myeloid leukemia, ischemic stroke, diabetic nephropathy, heart failure, acute lung injury and osteoporosis.

Cat. No.

A25144

CAS No.

3085711-53-8

DdBIC

DdBIC is a potent pyroptosis inducer that targets Nur77, facilitating its translocation to mitochondria. This interaction activates SDHA, leading to a depletion of succinyl-CoA, which disrupts heme homeostasis and causes electron leakage, culminating in increased mitochondrial reactive oxygen species (ROS) production. DdBIC further promotes oxidative activation of OMA1, resulting in OPA1 cleavage and subsequent release into the cytoplasm, which engages the integrated stress response via PERK. This cascade ultimately activates granzyme B, resulting in the cleavage of GSDMC. DdBIC is particularly relevant for research in melanoma studies.

Cat. No.

A25502

CAS No.

59061-53-9

ZIF-8

Synonyms: 2-Methylimidazole zinc salt

ZIF-8 (2-Methylimidazole zinc salt) is a pyroptosis inducer that activates cell death via a caspase-1/gasdermin D (GSDMD)-dependent mechanism. This compound exhibits significant anticancer properties by mediating inflammatory cell death, making it a valuable tool for studying pyroptosis in cancer research. Its ability to influence cellular responses positions ZIF-8 as a promising candidate for investigations into therapeutic interventions targeting pyroptotic pathways.

Cat. No.

A30107

CAS No.

33627-28-0

Britannin

Britannin is an autophagy inducer and NLRP3 inflammasome inhibitor with an IC50 of 3.630 μM. It exhibits significant anti-inflammatory effects by disrupting the interaction between NLRP3 and NEK7, effectively preventing NLRP3 activation and assembly. Additionally, Britannin shows antitumor properties by inhibiting tumor cell proliferation through interference with the interaction of HIF-1α and Myc, leading to reduced PD-L1 expression and enhanced activity of cytotoxic T lymphocytes. This compound also promotes apoptosis and autophagy in liver cancer cells via activation of ROS-regulated AMPK, making it a valuable tool for research in anti-inflammatory and oncology studies.

Cat. No.

A53969

CAS No.

31508-00-6

PenCB

Synonyms: PCB 118

PenCB (PCB 118) is a potent pyroptosis inducer that primarily activates the NFκB-dependent NLRP3 inflammasome pathway. Its mechanism involves the induction of oxidative stress, which is mediated through the activation of the aryl hydrocarbon receptor (AhR) and subsequent upregulation of cytochrome P450 1A1. This compound is useful for studies examining inflammatory processes and cell death mechanisms, particularly in the context of pyroptosis-related research.