JW-642

Catalog No.: A13774

MAGL inhibitor

JW-642 Chemical Structure

CAS NO. 1416133-89-5

JW-642 is a potent inhibitor of monoacylglycerol lipase (MAGL) that displays IC50 values of 7.6, 14, and 3.7 nM for inhibition of MAGL in mouse, rat, and human brain membranes, respectively.

Availability: In stock

Package Price Qty
10 mg
$70.00
25 mg
$150.00
50 mg
$250.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

JW-642 is a potent inhibitor of monoacylglycerol lipase (MAGL) that displays IC50 values of 7.6, 14, and 3.7 nM for inhibition of MAGL in mouse, rat, and human brain membranes, respectively.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.63 mL 108.13 mL 216.26 mL
0.5 mM 4.33 mL 21.63 mL 43.25 mL
1 mM 2.16 mL 10.81 mL 21.63 mL
5 mM 0.43 mL 2.16 mL 4.33 mL

*The above data is based on the productmolecular weight 462.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A13774
Actions Inhibitor
M. Wt 462.4
Formula C21H20F6N2O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1416133-89-5
Synonyms JW 642, JW642
SMILES O=C(OC(C(F)(F)F)C(F)(F)F)N1CCN(CC2=CC=CC(OC3=CC=CC=C3)=C2)CC1

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