K-14585 is a peptide that acts as a competitive antagonist of protease-activated receptor 2 (PAR2). It effectively inhibits PAR2-mediated interleukin-8 (IL-8) production, as well as phosphorylation of NF-κB and p38 MAPK signaling pathways. Additionally, K-14585 significantly reduces calcium mobilization induced by the PAR2 agonist SLIGKV in primary human keratinocytes, making it a valuable tool for studying PAR2-related biological processes and inflammatory responses.
K-14585 is a peptide that acts as a competitive antagonist of protease-activated receptor 2 (PAR2). It effectively inhibits PAR2-mediated interleukin-8 (IL-8) production, as well as phosphorylation of NF-κB and p38 MAPK signaling pathways. Additionally, K-14585 significantly reduces calcium mobilization induced by the PAR2 agonist SLIGKV in primary human keratinocytes, making it a valuable tool for studying PAR2-related biological processes and inflammatory responses.
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