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Kobe0065 inhibits anchorage-dependent and -independent growth, blocks MEK/ERK activity and induces apoptosis in H-rasG12V transformed NIH3T3 cells.
Targets
| H-Ras-cRaf1 interaction | ||||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 22.23 mL | 111.16 mL | 222.33 mL |
| 0.5 mM | 4.45 mL | 22.23 mL | 44.47 mL |
| 1 mM | 2.22 mL | 11.12 mL | 22.23 mL |
| 5 mM | 0.44 mL | 2.22 mL | 4.45 mL |
*The above data is based on the productmolecular weight 449.79. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A13135 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 449.79 |
| Formula | C15H11ClF3N5O4S |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 436133-68-5 |
| Synonyms | Kobe-0065 |
| SMILES | CC1=C(C=C(C=C1)NC(=S)NNC2=C(C=C(C=C2[N+](=O)[O-])C(F)(F)F)[N+](=O)[O-])Cl |
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United StatesAdooq Bioscience
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