Kobe0065

Name: Kobe0065
Brand: Adooq Bioscience
SKU: A13135
Rating: 100 (268 reviews)

Catalog No.: A13135

Ras-Raf interaction inhibitor

Kobe0065 Chemical Structure

CAS NO. 436133-68-5

Kobe0065 inhibits anchorage-dependent and -independent growth, blocks MEK/ERK activity and induces apoptosis in H-rasG12V transformed NIH3T3 cells.

Availability: In stock

Package	Price	Qty
10 mg	Regular Price: $50.00 Special Price $40.00
25 mg	Regular Price: $90.00 Special Price $72.00
50 mg	Regular Price: $135.00 Special Price $108.00
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Biological Activity

Kobe0065 inhibits anchorage-dependent and -independent growth, blocks MEK/ERK activity and induces apoptosis in H-rasG12V transformed NIH3T3 cells.

Targets

H-Ras-cRaf1 interaction

Solubility *

In vitro	DMSO	85 mg/mL (188.98 mM)
	Water	Insoluble
	Ethanol	12 mg/mL (26.68 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.23 mL	111.16 mL	222.33 mL
0.5 mM	4.45 mL	22.23 mL	44.47 mL
1 mM	2.22 mL	11.12 mL	22.23 mL
5 mM	0.44 mL	2.22 mL	4.45 mL

*The above data is based on the productmolecular weight 449.79. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A13135
Actions	Inhibitor
CAS No.	436133-68-5
Formula	C15H11ClF3N5O4S
M. Wt	449.79
Purity	>98%
Synonyms	Kobe-0065
SMILES	CC1=C(C=C(C=C1)NC(=S)NNC2=C(C=C(C=C2[N+](=O)[O-])C(F)(F)F)[N+](=O)[O-])Cl
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.