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Ras-Raf interaction inhibitor

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Catalog No. A13135

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Kobe0065 10mg A13135-10

Regular Price: $50.00

Special Price: $45.00

Kobe0065 25mg A13135-25

Regular Price: $90.00

Special Price: $81.00

Kobe0065 50mg A13135-50

Regular Price: $135.00

Special Price: $121.50

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Kobe0065 inhibits anchorage-dependent and -independent growth, blocks MEK/ERK activity and induces apoptosis in H-rasG12V transformed NIH3T3 cells.


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Chemical Information

Catalog Num A13135
Actions Inhibitor
M. Wt 449.79
Formula C15H11ClF3N5O4S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 436133-68-5
Synonyms Kobe-0065
SMILES CC1=C(C=C(C=C1)NC(=S)NNC2=C(C=C(C=C2[N+](=O)[O-])C(F)(F)F)[N+](=O)[O-])Cl

Biological Activity

Kobe0065 inhibits anchorage-dependent and -independent growth, blocks MEK/ERK activity and induces apoptosis in H-rasG12V transformed NIH3T3 cells.
H-Ras-cRaf1 interaction

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.23 mL 111.16 mL 222.33mL
0.5 mM 4.45 mL 22.23 mL 44.47 mL
1 mM 2.22 mL 11.12 mL 22.23 mL
5 mM 0.44 mL 2.22 mL 4.45 mL

*The above data is based on the productmolecular weight 449.79. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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