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Biological Activity
KPT185 is a selective CRM1 inhibitor. KPT-185 significantly inhibits leukemia cell proliferation with IC50 ranging from 100 nM to 500 nM, and induces cell-cycle arrest and apoptosis of AML cell lines and primary AML blasts.
Targets
| CRM1 | ||||
| In vitro | DMSO | 60 mg/mL (168.86 mM) | |
| Water | Insoluble | ||
| Ethanol | 60 mg/mL (168.86 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 28.14 mL | 140.72 mL | 281.44 mL |
| 0.5 mM | 5.63 mL | 28.14 mL | 56.29 mL |
| 1 mM | 2.81 mL | 14.07 mL | 28.14 mL |
| 5 mM | 0.56 mL | 2.81 mL | 5.63 mL |
*The above data is based on the productmolecular weight 355.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A12975 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1333151-73-7 |
| Formula | C16H16F3N3O3 |
| M. Wt | 355.31 |
| Purity | >98% |
| Synonyms | KPT 185, KPT-185 |
| SMILES | CC(C)OC(=O)C=CN1C=NC(=N1)C2=CC(=CC(=C2)OC)C(F)(F)F |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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