KPT185

Catalog No.: A12975

CRM1 Inhibitor

KPT185

KPT185 Chemical Structure

CAS NO. 1333151-73-7

KPT185 is a selective CRM1 inhibitor. KPT-185 significantly inhibits leukemia cell proliferation with IC50 ranging from 100 nM to 500 nM, and induces cell-cycle arrest and apoptosis of AML cell lines and primary AML blasts.

Availability: In stock

Package Price Qty
10 mg
$68.00
25 mg
$100.00
50 mg
$189.00
100 mg
$320.00
10mM * 1mL in DMSO
$60.00
Custom Size Get quote

Free Overnight Delivery on orders over $500

Next day delivery by 10:00 a.m. Order now.

Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

KPT185 is a selective CRM1 inhibitor. KPT-185 significantly inhibits leukemia cell proliferation with IC50 ranging from 100 nM to 500 nM, and induces cell-cycle arrest and apoptosis of AML cell lines and primary AML blasts.
Targets
CRM1
In vitro DMSO 60 mg/mL (168.86 mM)
Water Insoluble
Ethanol 60 mg/mL (168.86 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 28.14 mL 140.72 mL 281.44 mL
0.5 mM 5.63 mL 28.14 mL 56.29 mL
1 mM 2.81 mL 14.07 mL 28.14 mL
5 mM 0.56 mL 2.81 mL 5.63 mL

*The above data is based on the productmolecular weight 355.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A12975
Actions Inhibitor
CAS No. 1333151-73-7
Formula C16H16F3N3O3
M. Wt 355.31
Purity >98%
Synonyms KPT 185, KPT-185
SMILES CC(C)OC(=O)C=CN1C=NC(=N1)C2=CC(=CC(=C2)OC)C(F)(F)F
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Product Tags

Product Tags

Other people marked this product with these tags:

Use spaces to separate tags. Use single quotes (') for phrases.

Product Questions

Product Questions

No Questions
Keywords:buy KPT185 | KPT185 Supplier | purchase | cost | manufacturer | order | distributor | buy 1333151-73-7| 1333151-73-7 Supplier | purchase 1333151-73-7 | 1333151-73-7 cost | 1333151-73-7 manufacturer | order 1333151-73-7 | 1333151-73-7 distributor
Rewards