CaMK | Adooq Bioscience

Cat. No.: A66425

CAS No.: 3032691-65-6

CaMKK2-IN-1

CaMKK2-IN-1 is a selective inhibitor of calcium/calmodulin-dependent protein kinase kinase 2 (CaMKK2) with an IC50 of 7 nM. This compound displays high ligand efficiency, making it a valuable tool for investigating the role of CaMKK2 in cellular signaling pathways. Its application in research includes studies on metabolism, cancer, and neurological disorders where the modulation of CaMKK2 activity may provide insights into therapeutic interventions.

In stock View Details

5 mg

$325.00

10 mg

$565.00

All 5 sizes

Cat. No.: A66428

CAS No.: 2561494-76-4

SGC-CAMKK2-1

SGC-CAMKK2-1 is a selective inhibitor of calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2), exhibiting an IC50 of 30 nM. This compound effectively inhibits AMPK phosphorylation in C4-2 cells with an IC50 of 1.6 μM. SGC-CAMKK2-1 serves as a valuable chemical probe for investigating the role of CAMKK2 in various biological processes and pathways related to cellular energy regulation and metabolism.

In stock View Details

All 2 sizes

Cat. No.: A78504

CAS No.: 19115-49-2

Mevalonolactone

Mevalonolactone is a sesquiterpene lactone that acts as a calcineurin inhibitor, demonstrating inhibitory activity with an IC50 value of 134.29 μM against p-Nitrophenyl phosphate. This compound is primarily used in research exploring cellular signaling pathways, immune response modulation, and potential therapeutic applications for disorders involving calcineurin activity. Its ability to inhibit calcineurin makes it valuable for investigations into T cell activation and cytokine production.

In stock View Details

1 mg

$35.00

5 mg

$95.00

All 6 sizes

Cat. No.: A78505

CAS No.: 422546-87-0

NFAT Inhibitor-2

NFAT Inhibitor-2 is a selective inhibitor of calcineurin, targeting the calcium-regulated NFAT signaling pathway. This compound demonstrates significant potential in research related to inflammatory diseases, autoimmune disorders, cardiovascular conditions, neurodegenerative diseases, and disorders characterized by uncontrolled cell proliferation or differentiation. Additionally, NFAT Inhibitor-2 may provide insights into angiogenesis-related diseases, allergies, anaphylaxis, and alopecia.

In stock View Details

5 mg

$40.00

10 mg

$60.00

All 5 sizes

Cat. No.: A78507

CAS No.: 2388506-69-0

CS587

CS587 is a selective inhibitor of Calcium/calmodulin-dependent protein kinase 1D (CaMK1D), demonstrating neurocytotoxic effects at concentrations of 10 μM. This compound modulates neuronal cell sensitivity to amyloid-beta (Aβ) oligomer toxicity, making it a valuable tool for studying neurodegenerative disorders and related cellular pathways. Its specificity and mechanism of action position CS587 as a significant reagent for research into neuronal health and disease mechanisms.

In stock View Details

5 mg

$390.00

10 mg

$640.00

All 5 sizes

Cat. No.: A78509

CAS No.: 1026029-18-4

CaMKIIδ-IN-1

CaMKIIδ-IN-1 is a potent inhibitor of calcium/calmodulin-dependent protein kinase II delta (CaMKIIδ) with an IC50 of 12 nM. This pyrimidine-based compound is valuable for studying the role of CaMKIIδ in various cellular processes, including synaptic plasticity and cardiac function. Its selective inhibition makes it a useful tool for investigating the biochemical pathways regulated by CaMKIIδ in both physiological and pathological contexts.

In stock View Details

All 4 sizes

Cat. No.: A78510

CAS No.: 2493978-38-2

TIM-063

TIM-063 is a selective, cell-permeable CaMKK inhibitor that functions as an ATP-competitive antagonist, specifically targeting the catalytic domain of CaMKK. It exhibits Ki values of 0.35 μM for CaMKKα and 0.2 μM for CaMKKβ, with corresponding IC50 values of 0.63 μM and 0.96 μM. This compound is useful for exploring CaMKK-mediated signaling pathways and evaluating its potential therapeutic applications in various cellular models.

In stock View Details

5 mg

$280.00

10 mg

$460.00

All 5 sizes

Cat. No.: A78511

CAS No.: 3031484-08-6

CaMKIIα-IN-1

CaMKIIα-IN-1 is an orally active inhibitor of calcium/calmodulin-dependent protein kinase II alpha (CaMKIIα), exhibiting a dissociation constant (KD) of 219 nM for the wild-type hub. This compound demonstrates good metabolic stability, making it suitable for in vivo studies. It can be utilized in research focused on CaMKIIα-mediated pathways, with applications in understanding neurological diseases and cellular signaling mechanisms.

In stock View Details

5 mg

$45.00

10 mg

$75.00

All 5 sizes

Cat. No.: A78518

CAS No.: 867178-11-8

HOCPCA

HOCPCA is a selective inhibitor of CaMKIIα, a key regulator of calcium-dependent signaling pathways. This compound exhibits neuroprotective properties, enhancing sensorimotor functions and promoting hippocampal neuronal activity following experimental stroke in murine models. It effectively modulates abnormal CaMKII signaling, normalizes Thr286 autophosphorylation post-ischemia, and downregulates specific active CaMKII fragments associated with ischemic conditions. Additionally, HOCPCA demonstrates superior binding affinity to the GHB site, alongside excellent blood-brain barrier permeability, making it a valuable tool for research into neuroprotection and cognitive function.

In stock View Details

All 3 sizes

Cat. No.: A78519

CAS No.: 2765717-63-1

CaMKII-IN-3

CaMKII-IN-3 is a potent inhibitor of Calcium/Calmodulin-dependent protein kinase II (CaMKII), demonstrating an IC50 of less than 10 nM. This compound is valuable in research focused on the role of CaMKII in cardiac function and related heart diseases. Its application may provide insights into disease mechanisms and potential therapeutic strategies.

View Details

Out of stock

All 3 sizes

Cat. No.: A78522

CAS No.: 926319-75-7

Protein kinase inhibitor 8

Protein kinase inhibitor 8 (Compound CK59) is a selective inhibitor of calmodulin-dependent protein kinase II (CaMKII). This compound effectively reduces cytotoxicity induced by perfluorooctane sulfonic acid (PFOS) and mitigates the downregulation of GLT-1 expression, leading to decreased neuronal damage. Protein kinase inhibitor 8 is a valuable tool for research into neurodegenerative diseases and the molecular mechanisms underlying neuronal stress responses.

In stock View Details

All 3 sizes