Calmodulin

Cat. No.

A25401

CAS No.

179185-73-0

DY-9760e

DY-9760e is a selective calmodulin (CaM) inhibitor that disrupts the Ca²⁺/CaM complex, thereby inhibiting various calmodulin-dependent enzymes, including nNOS, CaM kinase II, and calcineurin (Ki values of 0.9, 1.4, and 2.0 μM, respectively). This compound effectively inhibits excessive nitric oxide production and protein tyrosine nitration, while also preventing the activation of calpain and caspase-3. DY-9760e has demonstrated potential in reducing infarct size, enhancing cardiac function, and mitigating oxidative stress and cell death, making it a valuable tool in research related to myocardial infarction, cerebral ischemia, and other related disorders.

Cat. No.

A33859

CAS No.

905954-17-8

Psoralenoside

Psoralenoside is a benzofuran glycoside that functions as a calmodulin inhibitor. It demonstrates significant binding affinity for histaminergic H1 receptors and voltage-gated L-type calcium channels, making it a valuable tool in studying calcium signaling pathways. Psoralenoside exhibits estrogen-like activity, promotes osteoblastic proliferation, and displays both antitumor and antibacterial properties, positioning it as a versatile reagent for research in cancer biology, bone metabolism, and pharmacology.

Cat. No.

A39760

CAS No.

1674-48-2

Metofenazate (diethanesulfonate)

Synonyms: Methophenazine (diethanesulfonate)

Metofenazate (diethanesulfonate) is a selective inhibitor of calmodulin, a key calcium-binding messenger protein. It modulates calmodulin-mediated signaling pathways, making it a valuable tool for studying calcium-dependent cellular processes. This compound is widely used in research to investigate various physiological and pathological conditions associated with calmodulin activity.

Cat. No.

A66426

CAS No.

120634-86-8

KS 501

KS 501 is a potent and selective inhibitor of calmodulin, primarily targeting calmodulin-dependent kinases I and II. By interfering with calmodulin activation, KS 501 effectively modulates downstream signaling without directly affecting cyclic adenosine 3’,5’-monophosphate (cAMP)-sensitive kinases. Its inhibitory action makes KS 501 a valuable tool for investigating the role of calmodulin in leukemia and other related biological pathways.

Cat. No.

A66434

CAS No.

78957-84-3

Calmodulin antagonist-1

Calmodulin Antagonist-1 is a selective inhibitor of calmodulin (CaM), designed to hinder calmodulin-activated calcium-dependent phosphodiesterase (PDE) with an IC50 of 66 μM. This compound also exhibits competitive inhibition of trypsin-treated Ca2+-PDE, showcasing an IC50 of 560 μM in relation to cyclic GMP. Its ability to modulate calmodulin activity makes it a valuable tool for investigating calcium signaling pathways and their implications in various biological processes.

Cat. No.

A66438

CAS No.

701914-77-4

Acremonidin A

Acremonidin A is a potent calmodulin (CaM) inhibitor derived from Purpureocillium lilacinum. It demonstrates a strong binding affinity for the human calmodulin biosensor hCaM M124C-mBBr, exhibiting a Kd value of 19.40 nM. This compound is valuable for research applications focused on elucidating the roles of calmodulin in calcium signaling pathways and its implications in various physiological processes.

Cat. No.

A66439

CAS No.

76265-41-3

Beauverolide Ja

Beauverolide Ja is a potent calmodulin (CaM) inhibitor, demonstrating a Kd of 0.078 μM and a Ki of 0.39 μM for the Ca2+-CaM complex. This cyclotetradepsipeptide, derived from the secondary metabolite of Isaria fumosorosea, is valuable for research investigating calmodulin's role in calcium signaling pathways. Its effective inhibition of calmodulin can facilitate studies into various biological processes and potential therapeutic applications.

Cat. No.

A66449

CAS No.

137592-47-3

Bisindolylmaleimide VII

Bisindolylmaleimide VII is a potent calmodulin inhibitor with a high binding affinity (Kd = 186.2 nM). This compound is instrumental in elucidating the role of calmodulin in various biological processes and disease states, including cancer, neurodegenerative disorders, and muscle dysfunction. Its application in research facilitates a deeper understanding of calmodulin's contribution to cellular signaling pathways and potential therapeutic interventions.

Cat. No.

B21471

CAS No.

69-43-2

Prenylamine lactate

Prenylamine lactate is a calcium-modulating protein (CaM) antagonist that effectively inhibits CaM-dependent enzymes, demonstrating the ability to induce relaxation in smooth muscle preparations. Notably, the action of Prenylamine lactate on smooth muscle is not counteracted by the calcium agonist Bay K 8644. Additionally, under conditions of lower heart rates, Prenylamine lactate has been reported to enhance voltage-dependent transmembrane calcium currents, making it a valuable tool for studying calcium signaling pathways and smooth muscle physiology.