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Dopamine Transporter

Dopamine transporter (DAT) inhibitors and probes act on the carrier that clears released dopamine. DAT was cloned as a cocaine-sensitive transporter, and mice lacking it show hyperlocomotion and no behavioral response to cocaine or amphetamine. The X-ray structure of the Drosophila transporter bound to an antidepressant revealed its central binding site. Listed compounds include LR1143 and SRI-32743, radafaxine hydrochloride, which inhibits dopamine and norepinephrine uptake, and DOV-102,677, which also blocks serotonin transport. IDT307 is a fluorescent transporter substrate used to measure monoamine uptake in cells.

3 Items

  • TFEB activator 2
    Cat. No.
    A39401
    CAS No.
    3027414-04-3

    TFEB activator 2

    TFEB Activator 2 is a potent oral compound that effectively crosses the blood-brain barrier, targeting the dopamine transporter (DAT). It promotes TFEB nuclear translocation and enhances lysosome biogenesis through modulation of the DAT-CDK9-TFEB signaling pathway. With demonstrated neuroprotective properties, this reagent is valuable for research applications related to Alzheimer's disease and other neurodegenerative conditions.

    In stock View Details
    5 mg
    $245.00
    10 mg
    $405.00
    All 5 sizes
  • EEDQ
    Cat. No.
    A45829
    CAS No.
    16357-59-8

    EEDQ

    EEDQ is a carboxylate activator and an irreversible antagonist at the 5HT2c receptors. It effectively reduces [3H]β-CIT binding to the dopamine transporter (DAT) in rat caudate-putamen (CPu) homogenates with an IC50 value of 78.3 μM. Additionally, EEDQ has demonstrated the ability to inhibit contralateral rotation behavior, making it a useful tool for studying dopamine signaling and behavioral responses in neuropharmacological research.

    In stock View Details
    25 mg
    $20.00
    50 mg
    $25.00
    All 4 sizes
  • 5,7-Dimethoxyluteolin
    Cat. No.
    A78893
    CAS No.
    90363-40-9

    5,7-Dimethoxyluteolin

    5,7-Dimethoxyluteolin is a derivative of 5,7-dimethylluteolin that acts as a dopamine transporter (DAT) activator, exhibiting an EC50 value of 3.417 μM. This compound enhances dopamine uptake and may play a crucial role in the modulation of dopaminergic signaling. It is useful in studies exploring neurotransmitter transport mechanisms and the physiological effects of dopamine in various neurological conditions.

    In stock View Details
    1 mg
    $45.00
    2 mg
    $70.00
    All 4 sizes

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