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Sigma Receptor

Sigma receptor ligands bind sigma-1 and sigma-2 receptors, two unrelated proteins that are not G protein-coupled. The sigma-1 receptor was cloned in 1996 and resembles a yeast sterol isomerase more than any known mammalian receptor. It resides mainly in the endoplasmic reticulum, and its 2016 crystal structure showed a trimer with one transmembrane helix per protomer. The gene for the sigma-2 receptor was identified in 2017 as transmembrane protein 97 (TMEM97). Cutamesine (SA4503) dihydrochloride, 4-IBP and pentoxyverine citrate are sigma-1 agonists, whereas S1RA and BD-1047 2HBr are sigma-1 antagonists. Siramesine is a sigma-2 agonist, and UMB24 a sigma-2 antagonist.

1 Item

  • CM764
    Cat. No.
    A79306
    CAS No.
    1350296-29-5

    CM764

    CM764 is a sigma receptor activator, exhibiting Ki values of 86.6 nM for the sigma-1 receptor and 3.5 nM for the sigma-2 receptor. This compound increases cytoplasmic calcium levels, enhances NAD+/NADH and ATP production, and reduces reactive oxygen species (ROS) concentration. CM764 is relevant for studies exploring sigma receptor pathways and their implications in cellular metabolism and oxidative stress.

    In stock View Details
    25 mg
    $1,275.00
    50 mg
    $1,625.00
    All 3 sizes

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