Purinergic (P2Y) Receptors

Cat. No.

A62815

CAS No.

73536-95-5

ADP-β-S trilithium

Synonyms: Adenosine 5'-β-thiodiphosphate (trilithium)

ADP-β-S trilithium is the trilithium salt form of ADP-β-S, serving as a potent activator of the P2Y12 receptor. It facilitates the upregulation of IL-1β and IL-6 production in microglial cells, promotes NF-κB phosphorylation and nuclear translocation, and enhances NLRP3 inflammasome activation. This reagent is valuable for research into inflammatory responses and signaling pathways involving P2Y12 receptor activation.

Cat. No.

A62871

CAS No.

71214-29-4

Sp-UTP-α-S

Synonyms: Uridine 5'-O-(1-thiotriphosphate)

Sp-UTP-α-S (Uridine 5'-O-1-thiotri-phosphate) functions as an activator of P2Y2 and P2Y4 receptors. This compound is particularly useful in cancer research, where it can help elucidate the roles of purinergic signaling in tumor biology. By activating these receptors, Sp-UTP-α-S may contribute to studies related to cell proliferation, migration, and signaling pathways associated with cancer progression.

Cat. No.

A62884

CAS No.

1352921-13-1

Ap4C tetrasodium

Ap4C tetrasodium is an activator of P2Y2 and P2Y4 receptors, functioning as a signaling molecule through its interaction with these purinergic receptors. It induces platelet aggregation and mediates various cellular responses, making it a key reagent in the study of inflammation and blood coagulation pathways. This compound is valuable for research applications focusing on the pharmacology of platelet function and related vascular processes.

Cat. No.

A62893

CAS No.

26184-65-6

P1,P2-Diuridine-5’-diphosphate

Synonyms: Up2U

P1,P2-Diuridine-5'-diphosphate (Up2U) is a symmetrical dinucleoside polyphosphate that acts as a purinergic P2Y receptor activator. This compound plays a significant role in modulating cellular responses by activating purinergic signaling pathways. It is of particular interest in research areas involving neurotransmission, cellular signaling, and immune responses. P1,P2-Diuridine-5'-diphosphate can be utilized to explore the functional roles of P2Y receptors in various biological systems.