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Imidazoline Receptor

Imidazoline receptor ligands act on the I1, I2 and I3 binding sites for imidazoline compounds. Imidazoline receptors were proposed when clonidine-like compounds were found to lower blood pressure through brainstem sites distinct from α2-adrenergic receptors. I1 sites take part in central blood pressure control, and I2 sites are linked to monoamine oxidase. I3 sites in pancreatic β cells are involved in the regulation of insulin secretion. Moxonidine hydrochloride and rilmenidine phosphate are listed as I1 agonists, and AGN 192403 as an I1 antagonist. Idazoxan hydrochloride blocks α2-adrenergic receptors and binds I2 sites, as does BU226 hydrochloride, while KU14R is an I3 antagonist. Clonidine hydrochloride and guanabenz acetate act mainly at α2-adrenergic receptors and are also listed under Adrenergic Receptors.

1 Item

  • Aganodine
    Cat. No.
    A78966
    CAS No.
    86696-87-9

    Aganodine

    Aganodine is a guanidine compound that functions as an imidazoline receptor activator. It plays a significant role in modulating neurotransmitter release by inhibiting electrically evoked [3H]-norepinephrine release from presynaptic sites. This compound is valuable for research applications focused on cardiovascular physiology and neuropharmacology, providing insights into imidazoline receptor signaling pathways.

    In stock View Details
    25 mg
    $1,405.00
    50 mg
    $1,790.00
    All 3 sizes

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