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NF-κB

NF-κB inhibitors act on the transcription factor family that switches on many inflammatory and immune response genes. Nuclear factor kappa B (NF-κB) was identified in 1986 as a B cell nuclear factor binding the immunoglobulin kappa enhancer. It forms dimers from five Rel family proteins, including RelA, also called p65. In resting cells, inhibitor of κB (IκB) proteins hold these dimers in the cytoplasm. This category focuses on compounds that affect NF-κB dimers, their nuclear entry, DNA binding or target gene expression. Representative compounds include JSH 23, QNZ, SC75741 and the natural product withaferin A. Compounds acting on the upstream IκB kinase complex are listed in the neighboring IκK/IκB category.

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  • oxLig-1
    Cat. No.
    A79667
    CAS No.
    352523-18-3

    oxLig-1

    Synonyms: 7-Ketocholesteryl-9-carboxynonanoate

    oxLig-1 (7-Ketocholesteryl-9-carboxynonanoate) is an NF-κB activator that functions as a key ligand for β-glycoprotein I (β(2)-GPI), derived from oxidized low-density lipoprotein (oxLDL). By promoting nuclear translocation, oxLig-1 initiates the NF-κB signaling pathway, which plays a significant role in various inflammatory processes. This compound is instrumental in research on atherosclerosis and offers insights into the mechanisms underlying lipid metabolism and cardiovascular diseases.

    In stock View Details
    1 mg
    $220.00
    5 mg
    $1,075.00
    All 6 sizes

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