NF-κB

Cat. No.

A15708

CAS No.

66280-25-9

Gomisin J

Gomisin J is a lignan derived from Schisandra chinensis that primarily acts as a calcium channel activator. It enhances nitric oxide bioavailability through eNOS activation and regulates lipid metabolism via the AMPK pathway. Additionally, Gomisin J exhibits anti-inflammatory effects by inhibiting fetuin-A and NF-κB, while its activation of Nrf2/HO-1 boosts antioxidant capacity. This compound is relevant for studies focused on hypertension, non-alcoholic fatty liver disease, and cerebral ischemia-reperfusion injury.

Cat. No.

A17543

CAS No.

512-69-6

Raffinose

Synonyms: Melitose

Raffinose serves as an Nrf2 activator and is known for its ability to modulate intestinal flora. It inhibits the TLR4-MyD88-NF-κB signaling pathway while promoting Nrf2 signaling, contributing to its anti-inflammatory, antioxidant, and immunomodulatory properties. This compound is orally active and is valuable in research applications focusing on inflammation and oxidative stress.

Cat. No.

A26035

CAS No.

81474-59-1

Candidusin A

Synonyms: CHNQD-0803

Candidusin A is a potent AMPK activator with a KD of 47.28 nM, isolated from the marine fungus Aspergillus candidus. This compound demonstrates significant cytotoxicity, inducing apoptosis in human prostate cancer cell lines such as 22Rv1, PC-3, and LNCaP. Additionally, Candidusin A reduces the expression of adipogenesis-related genes and fat deposition, while negatively regulating the NF-κB-TNFα inflammatory axis to mitigate inflammation. Its diverse biological activities make Candidusin A a valuable tool for research into non-alcoholic steatohepatitis (NASH) and liver injury.

Cat. No.

A26090

CAS No.

774603-05-3

12-Nitrolinoleate

Synonyms: 12-Nitro-9-cis,12-cis-octadecadienoic acid

12-Nitrolinoleate is a potent peroxisome proliferator-activated receptor γ (PPARγ) activator derived from linoleic acid through nitration. It effectively induces PPARγ-dependent gene expression in MCF-7 cells, demonstrating an EC50 of 0.045 μM. Additionally, 12-Nitrolinoleate exhibits anti-inflammatory properties by inhibiting NF-κB transcription in RAW 264.7 cells, along with reducing levels of pro-inflammatory cytokines such as IL-6, TNF-α, and CCL2 in response to LPS stimulation. This compound is valuable for research applications focused on metabolic regulation and inflammation.

Cat. No.

A30500

CAS No.

855-96-9

Eupatorin

Eupatorin is a flavonoid that functions primarily as an NF-κB expression reducer and an ERK 1/2 activator, while also modulating beta-adrenergic receptors and inhibiting calcium channels. It demonstrates significant antiproliferative and vasodilatory effects, inducing apoptosis and causing G2/M phase cell cycle arrest, alongside reactive oxygen species (ROS) production. Eupatorin has been shown to impact inflammatory mediators and calcium signaling pathways, making it relevant for research in breast cancer, hypertension, and leukemia. Metabolized by CYP1A1 and other CYP1 enzymes, Eupatorin yields bioactive metabolites that maintain antiproliferative properties.

Cat. No.

A30801

CAS No.

81075-52-7

Danshensu sodium

Synonyms: Dan shen suan A sodium; Salvianic acid A sodium

Danshensu sodium, a phenolic compound, serves as an Nrf2 activator, effectively inducing the Nrf2/HO-1 signaling pathway while inhibiting NF-κB activity. It diminishes reactive oxygen species (ROS) production, enhances antioxidant defenses, and suppresses intrinsic apoptosis. Additionally, Danshensu sodium exhibits significant antiviral properties against SARS-CoV-2, with an EC50 value of 0.97 μM. This compound is valuable for researching its anti-oxidative, anti-inflammatory, and anti-apoptotic effects, holding potential implications for COVID-19, cardiovascular, and cerebrovascular diseases.

Cat. No.

A30905

CAS No.

33606-81-4

Myricanol

Myricanol is a diarylheptanoid that acts as a Nampt activator, enhancing SIRT1 and PRDX5 activities. This compound exhibits notable anti-inflammatory properties and mitigates glucocorticoid-induced muscle atrophy while regulating inflammatory mediators. Additionally, it demonstrates growth inhibition and promotes apoptosis in human lung adenocarcinoma A549 cells. Myricanol is also implicated in neuroprotection via autophagy-mediated clearance of microtubule-associated protein tau and contributes to cardiovascular health by inhibiting key signaling pathways such as PDGFRβ and NF-κB. Its activation of mitochondrial transcription factor A (TFAM) further supports anti-renal fibrosis effects and improves insulin sensitivity through AMPK activation.

Cat. No.

A32522

CAS No.

93859-63-3

Isochamaejasmin

Isochamaejasmin is a biflavonoid that acts as a potent activator of NF-κB. It exhibits significant anti-cancer properties by inducing apoptosis through the mitochondrial pathway and causing DNA damage in AW1 cells. In addition, Isochamaejasmin demonstrates moderate antiplasmodial activity against P. falciparum with an IC50 of 7.3 μM, while maintaining relatively low cytotoxicity (CC50 of 29.0 μM), making it valuable for various biological research applications.

Cat. No.

A34901

CAS No.

2009-64-5

Neopterin

Synonyms: D-(+)-Neopterin; D-erythro-Neopterin

Neopterin is an immune system activator derived from GTP and is produced by activated macrophages. It exhibits significant biological activity by inhibiting NF-κB phosphorylation and promoting PPAR-γ expression, which helps mitigate vascular inflammation and atherogenesis. Neopterin is useful for research applications focused on cardiovascular diseases, inflammation-related disorders, and tumor immunomonitoring.

Cat. No.

A35778

CAS No.

9008-97-3

Phytohemagglutinin

Synonyms: PHA-M

Phytohemagglutinin (PHA-M) is a potent T-cell activator derived from the seeds of Phaseolus vulgaris. This lectin stimulates the proliferation of human mononuclear leukocytes, leading to the upregulation of ChAT mRNA and enhancing acetylcholine synthesis. Additionally, Phytohemagglutinin exerts dose- and time-dependent cytotoxic effects on THP-1 monocytes/macrophages, resulting in altered cellular morphology, organelle dysfunction, and increased expression of pro-inflammatory markers such as NF-κB, COX2, and IL-1β. It is valuable for research applications related to immunology and cell signaling pathways.

Cat. No.

A35780

CAS No.

9001-32-5

Fibrinogen (Bovine)

Fibrinogen (Bovine) is a glycoprotein that serves as a potent NF-κB activator, exhibiting selective proteolytic properties when activated by thrombin to form fibrin clots. It plays a critical role in regulating NF-κB activation in endothelial cells and enhances the expression of pro-inflammatory chemokines, including MCP-1. Fibrinogen is essential for understanding blood coagulation processes, thrombosis, atherosclerosis, and the pathological aspects of venous graft development, making it valuable for research in vascular diseases.

Cat. No.

A36100

CAS No.

1951464-78-0

c-(2'FdAMP-2'FdIMP)

c-(2'FdAMP-2'FdIMP) is a cyclic dinucleotide (CDN) that functions as a STING activator. It effectively stimulates STING-dependent signaling pathways, including IRF and NF-κB, leading to enhanced immune responses. This compound is valuable for research into STING-based immunotherapy applications, particularly in the context of cancer and infectious disease studies.

Cat. No.

A39915

CAS No.

508-75-8

Convallatoxin

Convallatoxin is a PPARγ activator derived from the plant Adonis amurensis. It exhibits significant anti-inflammatory effects by mitigating colitic inflammation through the activation of PPARγ and the suppression of NF-κB signaling pathways. Additionally, Convallatoxin serves as a substrate for P-glycoprotein, identifying Val982 as a critical amino acid for its transport. This compound also enhances ligand-induced micro-opioid receptor (MOR) endocytosis, demonstrating high potency and efficacy, making it valuable for research in inflammation and cellular signaling.

Cat. No.

A40184

CAS No.

82864-43-5

8(9)-EET ((8S,9R)-EET)

8(9)-EET is an arachidonic acid metabolite produced through the cytochrome P450 epoxide pathway. It serves as an effective substrate for cyclooxygenases COX-1 and COX-2 and exhibits significant biological activity by activating PPARα in HEK293 cells. Additionally, 8(9)-EET inhibits NF-κB activity induced by IL-1β, functioning both in a PPARα-dependent and -independent manner. The (8S,9R)-isomer of 8(9)-EET specifically induces vasoconstriction, leading to reduced renal plasma flow and glomerular filtration rate, making it a relevant compound for studies in renal and cardiovascular research.

Cat. No.

A40635

CAS No.

1221412-23-2

IMM-H007

Synonyms: WS070117

IMM-H007 is a potent AMPK (AMP-activated protein kinase) activator and TGFβ1 (transforming growth factor β1) antagonist. This compound exhibits cardioprotective effects by activating AMPK, which subsequently reduces endothelial inflammation through the inactivation of NF-κB and JNK/AP1 signaling pathways. Additionally, IMM-H007 regulates lipid metabolism, effectively resolving hepatic steatosis in high-fat diet-fed hamsters. It is suitable for research applications focused on nonalcoholic fatty liver disease (NAFLD) and inflammatory atherosclerosis.

Cat. No.

A53240

CAS No.

2138299-65-5

diABZI-4

diABZI-4 is a potent STING activator that enhances the host immune response through immunostimulatory activity. By promoting STING oligomerization, diABZI-4 activates the TBK1-IRF3 and NF-κB signaling pathways, leading to increased production of type I/III interferons and proinflammatory cytokines. This reagent demonstrates broad-spectrum antiviral efficacy against various viruses, including influenza A, SARS-CoV-2, and herpes simplex virus. diABZI-4 is instrumental in research related to COVID-19, respiratory viral infections, and the associated immunopathological mechanisms, making it a valuable tool for studying viral pathogenesis and developing therapeutic strategies.

Cat. No.

A57026

CAS No.

1203479-63-3

SRTCX1002

SRTCX1002 is a selective activator of the SIRT1 enzyme, functioning primarily through the promotion of p65 deacetylation, which subsequently inhibits NF-κB activity. This compound effectively suppresses inflammatory responses, demonstrated by its ability to inhibit stimuli-induced NF-κB transcriptional activation and reduce LPS-induced TNFα secretion, with IC50 values of 0.71 µM and 7.58 µM, respectively. SRTCX1002 serves as a valuable reagent for research focused on inflammation and related signaling pathways.

Cat. No.

A62815

CAS No.

73536-95-5

ADP-β-S trilithium

Synonyms: Adenosine 5'-β-thiodiphosphate (trilithium)

ADP-β-S trilithium is the trilithium salt form of ADP-β-S, serving as a potent activator of the P2Y12 receptor. It facilitates the upregulation of IL-1β and IL-6 production in microglial cells, promotes NF-κB phosphorylation and nuclear translocation, and enhances NLRP3 inflammasome activation. This reagent is valuable for research into inflammatory responses and signaling pathways involving P2Y12 receptor activation.

Cat. No.

A65504

CAS No.

95266-40-3

Trinexapac-ethyl

Trinexapac-ethyl is a selective anti-gibberellin plant growth regulator that functions as a SOD activator. It plays a crucial role in the modulation of plant growth by inhibiting gibberellin biosynthesis. This compound is widely utilized in agricultural research to enhance tolerance to abiotic stress and optimize crop yield through its effects on plant hormones.

Cat. No.

A75266

CAS No.

156101-09-6

Erinacine C

Erinacine C is a potent activator of the Nrf2 signaling pathway and an inhibitor of the NF-κB signaling pathway. This compound demonstrates significant antioxidant, neuroprotective, and anti-inflammatory properties, making it a valuable tool in research focused on oxidative stress and neurodegenerative diseases. Its biological activities support studies aimed at exploring therapeutic strategies for conditions associated with inflammation and cellular damage.

Cat. No.

A79553

CAS No.

2387524-59-4

NF-κΒ activator 1

NF-κB activator 1 is a potent activator of the NF-κB signaling pathway, exhibiting an EC50 of 0.9 μM. This compound effectively induces the expression of superoxide dismutase (SOD)2 mRNA, contributing to enhanced cellular antioxidant responses. NF-κB activator 1 is valuable for research applications focusing on inflammation, oxidative stress, and related signaling pathways.

Cat. No.

A79561

CAS No.

2375281-44-8

NF-κΒ activator 2

NF-κΒ Activator 2 is a potent and orally active NF-κB activator, exhibiting an EC50 of 1.58 μM. This compound enhances the expression and activation of NF-κB, leading to the induction of SOD2. NF-κΒ Activator 2 is useful in researching mechanisms related to amyotrophic lateral sclerosis (ALS) and other conditions associated with NF-κB signaling.

Cat. No.

A79580

CAS No.

1074-86-8

Indole-4-carboxaldehyde

Indole-4-carboxaldehyde functions as an NF-κB activator. This compound demonstrates the ability to attenuate the expression of inflammatory-related genes, including TNF-α and IFN-γ, in HepG2 cells, without exhibiting cytotoxic effects. Additionally, it reduces the formation of advanced glycation end products (AGEs) induced by methylglyoxal (MGO) and decreases the expression of the receptor for RAGE. Indole-4-carboxaldehyde is a valuable reagent for studies focused on hepatic steatosis and related inflammatory pathways.

Cat. No.

A79590

CAS No.

38451-63-7

Asatone

Asatone is an NF-κB activator derived from Radix et Rhizoma Asari. It exhibits anti-inflammatory properties by activating the NF-κB signaling pathway while downregulating phosphorylated MAPK pathways, including ERK, JNK, and p38. This compound is valuable for research focused on inflammation, immune response modulation, and signaling pathways associated with these biological processes.

Cat. No.

A79609

CAS No.

26172-55-4

Methylchloroisothiazolinone

Methylchloroisothiazolinone is a potent NF-κB activator known for its pro-inflammatory properties. It induces the expression of pro-inflammatory cytokines, including IL-1β, TNF-α, and IL-6, through the activation of the NF-κB signaling pathway and upregulation of TLR4. This compound is utilized in research focusing on allergic contact dermatitis and immunotoxicity mechanisms. Additionally, Methylchloroisothiazolinone demonstrates neurotoxic effects and has been shown to impair cholinesterase activity, leading to increased oxidative stress and detrimental impacts on aquatic organisms, specifically Mediterranean mussels.