Obeticholic Acid

Catalog No.: A13866

FXR agonist

Obeticholic Acid

Obeticholic Acid Chemical Structure

CAS NO. 459789-99-2

Obeticholic Acid is a potent and selective farnesoid X receptor (FXR) agonist with EC50 of 99 nM

Availability: In stock

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10 mg

Regular Price: $70.00

Special Price $56.00

50 mg

Regular Price: $135.00

Special Price $108.00

10mM * 1mL in DMSO

Regular Price: $55.00

Special Price $44.00

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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Tomasz Kostrzewski, .et al. A Microphysiological System for Studying Nonalcoholic Steatohepatitis, Hepatol Commun, 2019, 13 November

Biological Activity

Obeticholic Acid is a potent and selective farnesoid X receptor (FXR) agonist with EC50 of 99 nM
99 nM(EC50)
In vitro DMSO 76 mg/mL (180.68 mM)
Water Insoluble
Ethanol Warmed: 76 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.77 mL 118.87 mL 237.74 mL
0.5 mM 4.75 mL 23.77 mL 47.55 mL
1 mM 2.38 mL 11.89 mL 23.77 mL
5 mM 0.48 mL 2.38 mL 4.75 mL

*The above data is based on the productmolecular weight 420.63. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A13866
Actions Agonist
CAS No. 459789-99-2
Formula C26H44O4
M. Wt 420.63
Purity >98%
Synonyms INT-747, 6-ECDCA
SMILES CC[[email protected]@H]1[[email protected]@H]2C[[email protected]@H](CC[[email protected]@]2([[email protected]]3CC[[email protected]]4([[email protected]]([[email protected]@H]3[[email protected]@H]1O)CC[[email protected]@H]4[[email protected]](C)CCC(=O)O)C)C)O

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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