PPI-GIT1/β-Pix PPI-IN-1 is a potent inhibitor of the GIT1/β-Pix protein-protein interaction, exhibiting a KD value of 7.7 µM. By disrupting the GIT/PIX interaction, this compound effectively modulates the activation of downstream Rho GTPases Rac1 and Cdc42, which are critical in various signaling pathways. PPI-GIT1/β-Pix PPI-IN-1 is particularly relevant in cancer research, demonstrating significant inhibitory effects on the metastasis of gastric cancer.
PPI-GIT1/β-Pix PPI-IN-1 is a potent inhibitor of the GIT1/β-Pix protein-protein interaction, exhibiting a KD value of 7.7 µM. By disrupting the GIT/PIX interaction, this compound effectively modulates the activation of downstream Rho GTPases Rac1 and Cdc42, which are critical in various signaling pathways. PPI-GIT1/β-Pix PPI-IN-1 is particularly relevant in cancer research, demonstrating significant inhibitory effects on the metastasis of gastric cancer.
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