- Cat. No.
- A22574
SNIPER(CRABP)-11
Synonyms: SN-11; PROTAC cIAP1 degrader-4
SNIPER(CRABP)-11, also known as PROTAC cIAP1 degrader-4, is a potent protein degrader.
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SNIPERs are bifunctional degraders that use inhibitor of apoptosis proteins as the E3 ubiquitin ligase. Each specific and nongenetic IAP-dependent protein eraser (SNIPER) joins a target ligand through a linker to a ligand for an inhibitor of apoptosis protein (IAP). The bound IAP, such as cellular IAP 1 (cIAP1) or X-linked IAP (XIAP), ubiquitinates the target for proteasomal degradation. A 2010 study used methyl bestatin hybrids to degrade cellular retinoic acid-binding proteins (CRABPs), and SNIPER(CRABP)-11 follows that design. In 2017, Abelson kinase (ABL) inhibitors were joined to IAP ligands to degrade the oncogenic fusion protein breakpoint cluster region-ABL (BCR-ABL). SNIPER(ABL)-062 and SNIPER(ABL)-039 belong to this series, whereas SNIPER(BRD)-1 degrades bromodomain-containing protein 4 (BRD4).
Synonyms: SN-11; PROTAC cIAP1 degrader-4
SNIPER(CRABP)-11, also known as PROTAC cIAP1 degrader-4, is a potent protein degrader.