E3 Ligase Ligand-Linker Conjugates: VHL

Cat. No.: A79941

CAS No.: 2467965-70-2

Pomalidomide 5'-pip-acid

Pomalidomide 5'-pip-acid is a molecular glue that functions as a dual-target PROTAC degrader, specifically targeting CBP/p300 and BRD4. It exhibits significant antiproliferative activity against cancer cells, with an IC50 value of 2.73 nM. This compound is particularly relevant for research in prostate and colorectal cancer, offering a valuable tool for investigating targeted degradation pathways in oncogenesis.

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$25.00

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$45.00

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Cat. No.: A79962

CAS No.: 3065021-33-9

(E)-JP-2-196 TFA

(E)-JP-2-196 TFA is a molecular glue handle that specifically interacts with E3-ubiquitin ligases, including RNF126, LRSAM1, RNF40, MID2, and RNF14, in vitro. This compound facilitates the synthesis of molecular glue degraders, making it a valuable tool for studying targeted protein degradation and investigating ubiquitin-proteasome system pathways. Its unique binding capabilities lend themselves to various research applications in protein modulation and therapeutic development.

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5 mg

$65.00

10 mg

$110.00

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Cat. No.: A80104

CAS No.: 2597167-22-9

Azido-PEG2-VHL

Azido-PEG2-VHL is a multikinase degrader that serves as a versatile building block for the synthesis of PROTACs (proteolysis-targeting chimeras). This compound features an azide functionality, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with alkyne-functionalized molecules, such as those containing DBCO or BCN groups. Its application in targeted protein degradation makes it a valuable tool in chemical biology research.

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Cat. No.: A80123

CAS No.: 2399455-71-9

Lenalidomide 4'-alkyl-C3-azide

Lenalidomide 4'-alkyl-C3-azide is a click chemical reagent that incorporates an azide group into lenalidomide, facilitating the synthesis of PROTACs. As an orally active immunomodulator, lenalidomide acts as a ligand for the ubiquitin E3 ligase cereblon (CRBN). This compound is capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions with alkyne-containing molecules, as well as strain-promoted azide-alkyne cycloaddition (SPAAC) with DBCO or BCN groups, thereby enabling versatile modifications in chemical biology research.

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Cat. No.: A80355

CAS No.: 3033187-29-7

E3 Ligase Ligand-linker Conjugate 122

E3 Ligase Ligand-linker Conjugate 122 is a specialized reagent designed for the synthesis of PROTAC degraders, specifically NR-11c. It combines an E3 ligase ligand with a linker, facilitating targeted protein degradation through the ubiquitin-proteasome system. This compound is essential for studies focused on E3 ligase-mediated degradation pathways and therapeutic applications in targeted cancer therapies.

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