Catalog No.: A13254
Ubiquitin E1 Inhibitor
PYR-41 is a cell-permeable, irreversible ubiquitin-activating enzyme (E1) inhibitor (IC50 < 10 μM).
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PYR-41 10mg
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PYR-41 25mg
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PYR-41 50mg
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PYR-41 100mg
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PYR-41 10mM * 1mL in DMSO
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Biological Activity
Discription PYR-41 is a cell-permeable, irreversible ubiquitin-activating enzyme (E1) inhibitor (IC50 < 10 μM).
Target Value
Product Information
Catalog Num A13254
Formula C17H13N3O7
Molecular Weight 371.3
CAS Number 418805-02-4
SMILES CCOC(=O)C1=CC=C(C=C1)N2C(=O)/C(=C\C3=CC=C(O3)[N+](=O)[O-])/C(=O)N2
Synonyms PYR 41, PYR41

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

In vitro (25°C) DMSO 72 mg/mL (193.9 mM)
Water Insoluble
Ethanol Insoluble
In vivo 2% DMSO+30% PEG 300+5% Tween 80+ddH2O 1 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 26.93 mL 134.66 mL 269.32 mL
0.5 mM 5.39 mL 26.93 mL 53.86 mL
1 mM 2.69 mL 13.47 mL 26.93 mL
5 mM 0.54 mL 2.69 mL 5.39 mL
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