We use analytics and advertising cookies, which you can accept or reject; see our privacy policy.

Current choice:

Tie-2

Tie-2 inhibitors block the angiopoietin receptor, a tyrosine kinase found mainly on endothelial cells. The name stands for tyrosine kinase with immunoglobulin-like and epidermal growth factor-like domains 2. Mouse embryos lacking Tie-2 showed defects in vessel sprouting and remodeling, as reported in 1995. Angiopoietin-1 was isolated as an activating Tie-2 ligand in 1996, and angiopoietin-2 was described a year later as a natural antagonist. Signaling through Tie-2 therefore helps to control vessel maturation, stability and permeability. Tie2 kinase inhibitor and AMG-Tie2-1 are directed at this receptor. Altiratinib, cabozantinib free base and pexmetinib also block other kinases, such as vascular endothelial growth factor receptor 2 (VEGFR2) or p38 mitogen-activated protein kinase (p38 MAPK).

1 Item

  • Vasculotide
    Cat. No.
    A84778
    CAS No.
    1359657-45-6

    Vasculotide

    Vasculotide is a Tie-2 activator that mimics angiopoietin-1, inducing phosphorylation of the Tie-2 receptor. It exhibits anti-inflammatory properties and reduces vascular permeability, making it effective in ameliorating endotoxin-induced endothelial barrier dysfunction. Research applications include promoting angiogenesis in diabetic ulcer models and protecting against vascular leakage in murine abdominal sepsis, while also improving microcirculatory perfusion in rat models of hemorrhagic shock.

    In stock View Details
    1 mg
    $110.00
    5 mg
    $295.00
    All 3 sizes

1 Item

Added to your cart

View Cart Checkout

    Loading...