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Src

Src inhibitors act on the Src family of non-receptor tyrosine kinases, which relay receptor and adhesion signals. Cellular Src (c-Src) is kept inactive when its Src homology 2 (SH2) domain binds a phosphorylated tyrosine in its C-terminal tail. Src family kinases regulate cell adhesion, migration, proliferation and survival, and they also transmit signals from immune receptors. Dasatinib, bosutinib and saracatinib inhibit both Src and the Abelson tyrosine kinase (Abl). PP2, a pyrazolopyrimidine compound, is a widely used Src family inhibitor in cell signaling studies. Tirbanibulin, first reported as KX2-391, is a further Src inhibitor in this category.

Cat. No.

A12417

CAS No.

41964-07-2

Tolimidone (MLR 1023)

Synonyms: MLR1023

MLR 1023 is a selective allosteric activator of Lyn kinase (EC50 = 63 nM)

In stock View Details

5 mg

$35.00

10 mg

$65.00

All 6 sizes
Cat. No.

A13415

CAS No.

1162656-22-5

MCB-613

MCB-613 is a potent, pan steroid receptor coactivator (SRC) stimulator.

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1 mg

$30.00

2 mg

$45.00

All 8 sizes
Cat. No.

A39210

CAS No.

296792-62-6

(E/Z)-MCB-613

(E/Z)-MCB-613 is a pan-Steroid Receptor Coactivator (SRC) stimulator that enhances SRC activity in cancer cells. This leads to the overstimulation of reactive oxygen species (ROS) production, resulting in cell stress and apoptosis through a mechanism known as paraptosis. (E/Z)-MCB-613 serves as a cytotoxic agent with significant implications for cancer research, particularly in studies focusing on targeted cancer therapies and mechanisms of cell death.

In stock View Details

1 mg

$85.00

5 mg

$290.00

All 4 sizes

Src

Tolimidone (MLR 1023)

MCB-613

(E/Z)-MCB-613