SR-4995 is a selective ligand for α-β-hydrolase domain-containing 5 (ABHD5), promoting lipolysis through the activation of adipose triglyceride lipase (ATGL). By displacing ABHD5 from its inhibitory interaction with perilipin-1 (PLIN1) and perilipin-5 (PLIN5), SR-4995 enhances lipid mobilization in adipose and muscle tissues. This compound is valuable for research exploring metabolic regulation and the mechanisms of lipolysis beyond PKA-dependent signaling pathways.
SR-4995 is a selective ligand for α-β-hydrolase domain-containing 5 (ABHD5), promoting lipolysis through the activation of adipose triglyceride lipase (ATGL). By displacing ABHD5 from its inhibitory interaction with perilipin-1 (PLIN1) and perilipin-5 (PLIN5), SR-4995 enhances lipid mobilization in adipose and muscle tissues. This compound is valuable for research exploring metabolic regulation and the mechanisms of lipolysis beyond PKA-dependent signaling pathways.
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