TK4b

Catalog No.: A33367
JAK Inhibitor
TK4b is a potent Janus kinase (JAK) inhibitor, exhibiting IC50 values of 19.40 nM for JAK2 and 18.42 nM for JAK3. This compound demonstrates significant anti-proliferative effects and is relevant for research in lymphoid-derived diseases and leukemia. Its selective inhibition of JAK2 and JAK3 makes TK4b a valuable tool for studying the role of JAK signaling pathways in cancer biology.
Grouped product items
Size Price Stock Qty
25mg
$1,275.00
In stock
50mg
$1,625.00
In stock
100mg
$2,000.00
In stock
Bulk Size
Bulk Discount
Free Delivery on orders over $500
Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
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Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionTK4b is a potent Janus kinase (JAK) inhibitor, exhibiting IC50 values of 19.40 nM for JAK2 and 18.42 nM for JAK3. This compound demonstrates significant anti-proliferative effects and is relevant for research in lymphoid-derived diseases and leukemia. Its selective inhibition of JAK2 and JAK3 makes TK4b a valuable tool for studying the role of JAK signaling pathways in cancer biology.
Product Information
Catalog NumA33367
FormulaC21H22N2O2
Molecular Weight334.41
CAS Number2232890-81-0
SMILESO=C1N(C2=CC=C(C)C(C)=C2)N(CC)C(C)=C1C(C3=CC=CC=C3)=O
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