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Biological Activity
BMS-911543 is an orally available small molecule targeting a subset of Janus-associated kinase (JAK) with potential antineoplastic activity.
Targets
| JAK2 | SET-2 | TYK2 | JAK3 | JAK1 |
| 1.1 nM | 60 nM | 66 nM | 75 nM | 360 nM |
| In vitro | DMSO | 36 mg/mL (83.23 mM) | |
| Water | Insoluble | ||
| Ethanol | 22 mg/mL (50.86 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 23.12 mL | 115.6 mL | 231.2 mL |
| 0.5 mM | 4.62 mL | 23.12 mL | 46.24 mL |
| 1 mM | 2.31 mL | 11.56 mL | 23.12 mL |
| 5 mM | 0.46 mL | 2.31 mL | 4.62 mL |
*The above data is based on the productmolecular weight 432.52. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A11241 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1271022-90-2 |
| Formula | C23H28N8O |
| M. Wt | 432.52 |
| Purity | >98% |
| Synonyms | BMS911543, BMS 911543 |
| SMILES | CCN1C(=CC2=C3C(=C(N=C21)NC4=NN(C(=C4)C)C)N=CN3C)C(=O)N(C5CC5)C6CC6 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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