BMS-911543

Catalog No.: A11241

JAK inhibitor

BMS-911543

BMS-911543 Chemical Structure

CAS NO. 1271022-90-2

BMS-911543 is an orally available small molecule targeting a subset of Janus-associated kinase (JAK) with potential antineoplastic activity.

Availability: In stock

Package Price Qty
5 mg
$100.00
10 mg
$180.00
25 mg
$380.00
50 mg
$700.00
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Biological Activity

BMS-911543 is an orally available small molecule targeting a subset of Janus-associated kinase (JAK) with potential antineoplastic activity.
Targets
JAK2 SET-2 TYK2 JAK3 JAK1
1.1 nM60 nM66 nM75 nM360 nM
In vitro DMSO 36 mg/mL (83.23 mM)
Water Insoluble
Ethanol 22 mg/mL (50.86 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.12 mL 115.6 mL 231.2 mL
0.5 mM 4.62 mL 23.12 mL 46.24 mL
1 mM 2.31 mL 11.56 mL 23.12 mL
5 mM 0.46 mL 2.31 mL 4.62 mL

*The above data is based on the productmolecular weight 432.52. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11241
Actions Inhibitor
CAS No. 1271022-90-2
Formula C23H28N8O
M. Wt 432.52
Solubility DMSO
Purity >98%
Synonyms BMS911543, BMS 911543
SMILES CCN1C(=CC2=C3C(=C(N=C21)NC4=NN(C(=C4)C)C)N=CN3C)C(=O)N(C5CC5)C6CC6
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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