TP0427736 HCl
ALK5 inhibitor
Important Notice: For research use only. We do not sell to patients.
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ALK5 inhibitor
Important Notice: For research use only. We do not sell to patients.
Not your Region? View all Distributors
Discription | TP0427736 is a potent inhibitor of ALK5 kinase activity with an IC50 of 2.72 nM and this effect is 300-fold higher than the inhibitory effect on ALK3 (IC50 = 836 nM for ALK3). It also inhibits Smad2/3 phosphorylation in A549 cells induced by TGF-β1 with an IC50 value of 8.68 nM. |
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Catalog Num | A22382 |
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Formula | C14H11ClN4S2 |
Molecular Weight | 334.85 |
CAS Number | 2459963-17-6 (HCl), 864374-00-5 |
SMILES | CC1=CSC(=N1)C2=C(N=CN2)C3=CC4=C(C=C3)N=CS4.Cl |
Synonyms | TP 0427736 HCl,TP-0427736 HCl |
Storage | Store lyophilized at -20ºC, keep desiccated. |
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2