TP0427736 HCl

Name: TP0427736 HCl
Brand: Adooq Bioscience
SKU: A22382
Rating: 5 (288 reviews)

Catalog No.: A22382

ALK5 inhibitor

TP0427736 is a potent inhibitor of ALK5 kinase activity with an IC50 of 2.72 nM and this effect is 300-fold higher than the inhibitory effect on ALK3 (IC50 = 836 nM for ALK3). It also inhibits Smad2/3 phosphorylation in A549 cells induced by TGF-β1 with an IC50 value of 8.68 nM.

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TP0427736 HCl 2459963-17-6 (HCl), 864374-00-5 <p>ALK5 inhibitor</p>

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Grouped product items
Size	Price	Stock
2mg	$90.00	In stock
5mg	$100.00	In stock
10mg	$160.00	In stock
25mg	$310.00	In stock
50mg	$495.00	In stock
100mg	$810.00	In stock
Bulk Size	Bulk Discount

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Biological Activity

Description	TP0427736 is a potent inhibitor of ALK5 kinase activity with an IC50 of 2.72 nM and this effect is 300-fold higher than the inhibitory effect on ALK3 (IC50 = 836 nM for ALK3). It also inhibits Smad2/3 phosphorylation in A549 cells induced by TGF-β1 with an IC50 value of 8.68 nM.

Product Information

Catalog Num	A22382
Formula	C14H11ClN4S2
Molecular Weight	334.85
CAS Number	2459963-17-6 (HCl), 864374-00-5
SMILES	CC1=CSC(=N1)C2=C(N=CN2)C3=CC4=C(C=C3)N=CS4.Cl
Synonyms	TP 0427736 HCl,TP-0427736 HCl
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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