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Sodium Channels

Sodium channel blockers act on voltage-gated sodium channels, which start and propagate action potentials. Voltage-gated sodium (NaV) channels open within milliseconds of depolarization and let sodium ions enter nerve and muscle cells. The first channel sequence, from the electric eel, was deduced from complementary DNA in 1984. A crystal structure of the sodium channel from Arcobacter butzleri (NavAb), reported in 2011, showed its pore and voltage-sensing modules at atomic resolution. Local anesthetics such as lidocaine and bupivacaine HCl block the channel pore in nerve conduction studies. Carbamazepine and disopyramide are used to study neuronal and cardiac excitability. The set also includes amiloride HCl, a blocker of the epithelial sodium channel (ENaC), and digoxin, an inhibitor of the sodium-potassium pump.

4 Items

  • Veratridine
    Cat. No.
    A24786
    CAS No.
    71-62-5

    Veratridine

    Synonyms: 3-Veratroylveracevine

    Veratridine is a potent agonist of voltage-gated sodium channels (VGSCs). This plant-derived neurotoxin enhances sodium ion permeability by preventing channel inactivation, thereby inducing prolonged sodium ion flow across the membrane. Veratridine is particularly effective on the Nav1.7 channel, exhibiting an IC50 of 18.39 µM, making it useful for research studies focused on ion channel modulation and neurophysiology.

    In stock View Details
    1 mg
    $35.00
    5 mg
    $100.00
    All 5 sizes
  • Propylparaben sodium
    Cat. No.
    A31961
    CAS No.
    35285-69-9

    Propylparaben sodium

    Synonyms: Propyl parahydroxybenzoate sodium; Propyl 4-hydroxybenzoate sodium

    Propylparaben sodium acts as a weak estrogen receptor agonist and serves as a voltage-gated sodium channel blocker, while also modulating the PI3K-AKT and JNK signaling pathways. It is known to induce oxidative stress, affecting the estrous cycle and hormone levels, as well as ovarian reserve function. Propylparaben sodium can inhibit the growth of antral follicles and influence the accumulation of steroid hormones in follicle culture media. This compound is suitable for research related to ovarian aging and myocardial ischemia-reperfusion injury.

    In stock View Details
    5 mg
    $20.00
    100 mg
    $25.00
    All 4 sizes
  • Cevadine
    Cat. No.
    A52365
    CAS No.
    62-59-9

    Cevadine

    Cevadine is a voltage-sensitive sodium channel agonist that exhibits insecticidal activity. This compound acts by enhancing sodium ion influx through channels, leading to disruption of neuromuscular function in target organisms. Cevadine is valuable for research in neurobiology and agricultural sciences, particularly in studying sodium channel dynamics and developing pest control strategies.

    In stock View Details
    1 mg
    $190.00
    5 mg
    $600.00
    All 3 sizes
  • Dimethyl lithospermate B
    Cat. No.
    A68473
    CAS No.
    875313-64-7

    Dimethyl lithospermate B

    Synonyms: dmLSB

    Dimethyl lithospermate B is a selective sodium channel agonist that enhances sodium current (INa) by slowing its inactivation. This activity results in an increased inward current during the early phases of the action potential (AP). Dimethyl lithospermate B is utilized in research applications focusing on cardiac and neuronal excitability.

    In stock View Details
    1 mg
    $120.00
    2 mg
    $185.00
    All 8 sizes

4 Items

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