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SGLT

Sodium-glucose cotransporter (SGLT) inhibitors block carriers that couple glucose uptake to sodium entry. SGLT1, cloned from rabbit intestine in 1987, absorbs glucose and galactose across the small intestinal epithelium. SGLT2 in the early proximal tubule reabsorbs most of the glucose filtered by the kidney. Phlorizin, a dihydrochalcone glucoside from apple tree bark, was the first known SGLT inhibitor and blocks both isoforms. Phloretin, the aglycone of phlorizin, also inhibits SGLT1 and SGLT2 in transport assays. Synthetic gliflozins such as dapagliflozin, empagliflozin and canagliflozin are selective for SGLT2. LX-4211, also called sotagliflozin, inhibits both SGLT1 and SGLT2 and is used to compare intestinal and renal glucose transport.

1 Item

  • Swertisin
    Cat. No.
    A50906
    CAS No.
    6991-10-2

    Swertisin

    Swertisin is an adenosine A1 receptor antagonist with additional SGLT2 inhibitory activity. This compound exhibits various biological functions, including anti-diabetic and antioxidant properties, as well as the ability to inhibit hepatitis B virus (HBV). Research has demonstrated that Swertisin can enhance cognitive function and alleviate memory impairments in murine models, making it a valuable tool for studies in diabetes, neuroprotection, and viral infections.

    In stock View Details
    1 mg
    $50.00
    5 mg
    $215.00
    All 5 sizes

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