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Serotonin Transporter

Serotonin transporter inhibitors block the reuptake of serotonin from the synapse into presynaptic neurons. The serotonin transporter (SERT), encoded by solute carrier family 6 member 4 (SLC6A4), couples serotonin uptake to sodium and chloride transport. Two groups cloned the transporter from rat brain in 1991 and showed its sensitivity to antidepressants. X-ray structures of human SERT bound to paroxetine and (S)-citalopram, reported in 2016, located the central inhibitor binding site. Selective inhibitors include fluoxetine hydrochloride, fluvoxamine maleate and paroxetine mesylate. Venlafaxine hydrochloride and duloxetine also block the norepinephrine transporter, as does the tricyclic compound imipramine hydrochloride.

1 Item

  • Nor mianserin hydrochloride
    Cat. No.
    A79222
    CAS No.
    76134-77-5

    Nor mianserin hydrochloride

    Nor Mianserin Hydrochloride is a serotonin antagonist, acting primarily on serotonin receptors to modulate serotonergic signaling. This compound is utilized in research focused on disorders linked to serotonin metabolism, as well as conditions associated with histamine metabolism. Its pharmacological profile makes it a valuable tool for studying various neuropsychiatric and metabolic diseases.

    In stock View Details
    5 mg
    $215.00
    10 mg
    $375.00
    All 4 sizes

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